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Prevalence of drug-herb and drug-supplement interactions in older adults : A cross-sectional survey. / Agbabiaka, Taofikat ; Spencer, Neil; Khanom, Sabina; Goodman, Claire.

In: British Journal of General Practice, Vol. 68, No. 675, bjgp18X699101, 10.2018, p. e711-e717.

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@article{af1e6080453f44b4980d9a6af242fcfe,
title = "Prevalence of drug-herb and drug-supplement interactions in older adults: A cross-sectional survey",
abstract = "Background Polypharmacy is common among older adults, with increasing numbers also using prescription drugs with herbal medicinal products (HMPs) and dietary supplements. There is no reliable evidence from the UK on concurrent use of HMPs and dietary supplements with prescription drugs in older adults. Aim To establish prevalence of concurrent prescription drugs, HMPs, and dietary supplements among UK community-dwelling older adults and identify potential interactions. Design and setting Cross-sectional survey of older adults registered at two general practices in South East England. Method A questionnaire asking about prescription medications, HMPs, and sociodemographic information was posted to 400 older adults aged ≥65 years, identified as taking ≥1 prescription drug. Results In total 155 questionnaires were returned (response rate = 38.8{\%}) and the prevalence of concurrent HMPs and dietary supplements with prescriptions was 33.6{\%}. Females were more likely than males to be concurrent users (43.4{\%} versus 22.5{\%}; P = 0.009). The number of HMPs and dietary supplements ranged from 1 to 8, (mean = 3, median = 1; standard deviation = 1.65). The majority of concurrent users (78.0{\%}) used dietary supplements with prescription drugs. The most commonly used dietary supplements were cod liver oil, glucosamine, multivitamins, and Vitamin D. Others (20.0{\%}) used only HMPs with prescription drugs. Common HMPs were evening primrose oil, valerian, and Nytol Herbal{\circledR} (a combination of hops, gentian, and passion flower). Sixteen participants (32.6{\%}) were at risk of potential adverse drug interactions. Conclusion GPs should routinely ask questions regarding herbal and supplement use, to identify and manage older adults at potential risk of adverse drug interactions.",
keywords = "Dietary supplements, General practice, Herb-drug interactions, Herbal medicine, Polypharmacy",
author = "Taofikat Agbabiaka and Neil Spencer and Sabina Khanom and Claire Goodman",
note = "{\circledC} British Journal of General Practice",
year = "2018",
month = "10",
doi = "10.3399/bjgp18X699101",
language = "English",
volume = "68",
pages = "e711--e717",
journal = "British Journal of General Practice",
issn = "0960-1643",
publisher = "Royal College of General Practitioners",
number = "675",

}

RIS

TY - JOUR

T1 - Prevalence of drug-herb and drug-supplement interactions in older adults

T2 - A cross-sectional survey

AU - Agbabiaka, Taofikat

AU - Spencer, Neil

AU - Khanom, Sabina

AU - Goodman, Claire

N1 - © British Journal of General Practice

PY - 2018/10

Y1 - 2018/10

N2 - Background Polypharmacy is common among older adults, with increasing numbers also using prescription drugs with herbal medicinal products (HMPs) and dietary supplements. There is no reliable evidence from the UK on concurrent use of HMPs and dietary supplements with prescription drugs in older adults. Aim To establish prevalence of concurrent prescription drugs, HMPs, and dietary supplements among UK community-dwelling older adults and identify potential interactions. Design and setting Cross-sectional survey of older adults registered at two general practices in South East England. Method A questionnaire asking about prescription medications, HMPs, and sociodemographic information was posted to 400 older adults aged ≥65 years, identified as taking ≥1 prescription drug. Results In total 155 questionnaires were returned (response rate = 38.8%) and the prevalence of concurrent HMPs and dietary supplements with prescriptions was 33.6%. Females were more likely than males to be concurrent users (43.4% versus 22.5%; P = 0.009). The number of HMPs and dietary supplements ranged from 1 to 8, (mean = 3, median = 1; standard deviation = 1.65). The majority of concurrent users (78.0%) used dietary supplements with prescription drugs. The most commonly used dietary supplements were cod liver oil, glucosamine, multivitamins, and Vitamin D. Others (20.0%) used only HMPs with prescription drugs. Common HMPs were evening primrose oil, valerian, and Nytol Herbal® (a combination of hops, gentian, and passion flower). Sixteen participants (32.6%) were at risk of potential adverse drug interactions. Conclusion GPs should routinely ask questions regarding herbal and supplement use, to identify and manage older adults at potential risk of adverse drug interactions.

AB - Background Polypharmacy is common among older adults, with increasing numbers also using prescription drugs with herbal medicinal products (HMPs) and dietary supplements. There is no reliable evidence from the UK on concurrent use of HMPs and dietary supplements with prescription drugs in older adults. Aim To establish prevalence of concurrent prescription drugs, HMPs, and dietary supplements among UK community-dwelling older adults and identify potential interactions. Design and setting Cross-sectional survey of older adults registered at two general practices in South East England. Method A questionnaire asking about prescription medications, HMPs, and sociodemographic information was posted to 400 older adults aged ≥65 years, identified as taking ≥1 prescription drug. Results In total 155 questionnaires were returned (response rate = 38.8%) and the prevalence of concurrent HMPs and dietary supplements with prescriptions was 33.6%. Females were more likely than males to be concurrent users (43.4% versus 22.5%; P = 0.009). The number of HMPs and dietary supplements ranged from 1 to 8, (mean = 3, median = 1; standard deviation = 1.65). The majority of concurrent users (78.0%) used dietary supplements with prescription drugs. The most commonly used dietary supplements were cod liver oil, glucosamine, multivitamins, and Vitamin D. Others (20.0%) used only HMPs with prescription drugs. Common HMPs were evening primrose oil, valerian, and Nytol Herbal® (a combination of hops, gentian, and passion flower). Sixteen participants (32.6%) were at risk of potential adverse drug interactions. Conclusion GPs should routinely ask questions regarding herbal and supplement use, to identify and manage older adults at potential risk of adverse drug interactions.

KW - Dietary supplements

KW - General practice

KW - Herb-drug interactions

KW - Herbal medicine

KW - Polypharmacy

UR - http://www.scopus.com/inward/record.url?scp=85054057638&partnerID=8YFLogxK

U2 - 10.3399/bjgp18X699101

DO - 10.3399/bjgp18X699101

M3 - Article

VL - 68

SP - e711-e717

JO - British Journal of General Practice

JF - British Journal of General Practice

SN - 0960-1643

IS - 675

M1 - bjgp18X699101

ER -