University of Hertfordshire

From the same journal

From the same journal

By the same authors

  • Mustafa Alomari
  • Parameswara R Vuddanda
  • Sarah J Trenfield
  • Cornelius C Dodoo
  • Sitaram Velaga
  • Abdul W Basit
  • Simon Gaisford
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Original languageEnglish
Number of pages7
Pages (from-to)363-369
JournalInternational Journal of Pharmaceutics
Journal publication date5 Oct 2018
Volume549
Issue1-2
DOIs
Publication statusPublished - 5 Oct 2018
Externally publishedYes

Abstract

Hypothyroidism is a chronic and debilitating disease that is estimated to affect 3% of the general population. Clinical experience has highlighted the synergistic value of combining triiodothyronine (T 3) and thyroxine (T 4) for persistent or recurrent symptoms. However, thus far a platform that enables the simultaneous and independent dosing of more than one drug for oral administration has not been developed. Thermal inkjet (TIJ) 2D printing is a potential solution to enable the dual deposition of T 3 and T 4 onto orodispersible films (ODFs) for therapy personalisation. In this study, a two-cartridge TIJ printer was modified such that it could print separate solutions of T 3 and T 4. Dose adjustments were achieved by printing solutions adjacent to each other, enabling therapeutic T 3 (15–50 μg) and T 4 dosages (60–180 μg) to be successfully printed. Excellent linearity was observed between the theoretical and measured dose for both T 3 and T 4 (R 2 = 0.982 and 0.985, respectively) by changing the length of the print objective (Y-value). Rapid disintegration of the ODFs was achieved (<45 s). As such, this study for the first time demonstrates the ability to produce personalised dose combinations by TIJ printing T 3 and T 4 onto the same substrate for oral administration.

Notes

Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

ID: 16186467