University of Hertfordshire

From the same journal

  • Amanda Baxter
  • Meredith Harris
  • Yasmin Khatib
  • Traolach Brugha
  • Hiedrun Bien
  • Kamaldeep Bhui
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Original languageEnglish
Pages (from-to)322-329
Number of pages8
JournalBritish Journal of Psychiatry
Publication statusPublished - Apr 2016


BackgroundPeople with severe mental illness (SMI) have high rates of chronic disease and premature death.AimsTo explore the strength of evidence for interventions to reduce risk of mortality in people with SMI.MethodIn a meta-review of 16 systematic reviews of controlled studies, mortality was the primary outcome (8 reviews). Physiological health measures (body mass index, weight, glucose levels, lipid profiles and blood pressure) were secondary outcomes (14 reviews).ResultsAntipsychotic and antidepressant medications had some protective effect on mortality, subject to treatment adherence. Integrative community care programmes may reduce physical morbidity and excess deaths, but the effective ingredients are unknown. Interventions to improve unhealthy lifestyles and risky behaviours can improve risk factor profiles, but longer follow-up is needed. Preventive interventions and improved medical care for comorbid chronic disease may reduce excess mortality, but data are lacking.ConclusionsImproved adherence to pharmacological and physical health management guidelines is indicated.

ID: 17632759