University of Hertfordshire

Revised upper limb module for spinal muscular atrophy: 12 month changes

Research output: Contribution to journalArticle

  • iSMAC Consortium Group
  • Maria Carmela Pera
  • Giorgia Coratti
  • Elena S Mazzone
  • Jacqueline Montes
  • Mariacristina Scoto
  • Roberto De Sanctis
  • Marion Main
  • Anna Mayhew
  • Robert Muni Lofra
  • Sally Dunaway Young
  • Allan M Glanzman
  • Tina Duong
  • Amy Pasternak
  • Danielle Ramsey
  • Basil Darras
  • John W Day
  • Richard S Finkel
  • Darryl C De Vivo
  • Maria Pia Sormani
  • Francesca Bovis
  • Volker Straub
  • Francesco Muntoni
  • Marika Pane
  • Eugenio Mercuri
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Original languageEnglish
Number of pages5
Pages (from-to)426-430
JournalMuscle & nerve
Journal publication date1 Apr 2019
Volume59
Issue4
DOIs
Publication statusPublished - 1 Apr 2019
Externally publishedYes

Abstract

INTRODUCTION: The aim of the study was to assess 12 month changes in upper limb function in patients affected by spinal muscular atrophy type 2 and 3.

METHODS: Longitudinal 12 month data was collected in 114 patients, 60 type 2 and 54 type 3, using the Revised Upper Limb Module.

RESULTS: The 12 month changes ranged between -7 and 9 (mean: -0.41; SD: 2.93). The mean changes were not significantly different between the three spinal muscular atrophy groups (-0.45 in type 2, -0.23 in non-ambulant type 3 and -0.34 in ambulant type 3, p = 0.96) and the relationship between 12 month change and age classes was not significantly different among the three types of SMA patients.

DISCUSSION: Our results confirm that the Module explores a wide range of functional abilities and can be used in ambulant and non-ambulant patients of different ages in conjunction with other functional scales. Muscle Nerve 59:426-430, 2019.

Notes

© 2019 Wiley Periodicals, Inc.

ID: 16612001