University of Hertfordshire

From the same journal

From the same journal

By the same authors

View graph of relations
Original languageEnglish
Pages (from-to)40-49
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume363
Issue1-2
DOIs
Publication statusPublished - 3 Nov 2008

Abstract

The use of chemical penetration enhancers (CPE) is growing due to their ability to improve drug delivery through the skin. A possible mechanism of penetration enhancement could involve the complex formation between drug and components in the pharmaceutical formulation, thus altering the physicochemical properties of the active substance. Here, modelling studies indicate that hydrocarbon and oxygen-containing terpenes (penetration enhancers) could form complexes with drugs. Satisfactory correlations have been obtained between the predicted molecular properties of enhancers and their enhancement effects

ID: 1447744