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Statistical evaluation of influence of viscosity and content of polymer on dipyridamole release from floating matrix tablets: a technical note. / Patel, Viralkumar; Patel, Natavarlal M.

In: AAPS PharmSciTech, Vol. 8, No. 3, 09.2007, p. E140-E144.

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@article{4107b12ec1ba4f2d8797433a3a343e03,
title = "Statistical evaluation of influence of viscosity and content of polymer on dipyridamole release from floating matrix tablets: a technical note",
abstract = "The present investigation described the influence of viscosity and content of HPMC on dipyridamole release using 32 full factorial design. All formulations had desired floating lag time (<2 minutes) regardless of viscosity and content of polymeric matrices. Results of multiple regression analysis indicate that both factors significantly affect the diffusion exponent (n), release rate constant (k), and percentage drug release at 1 hour, 4 hours, 6 hours, and 12 hour, (P<.05). Mechanism of drug release was found to be anomalous type to case-II transport depending upon the viscosity and content of polymer. It was found that content of HPMC had a dominant role in the initial phase of drug release, while in the later phase viscosity of HPMC Predominated",
keywords = "Diffusion, Dipyridamole, Methylcellulose, Regression Analysis, Solubility, Tablets, Viscosity",
author = "Viralkumar Patel and Patel, {Natavarlal M.}",
year = "2007",
month = "9",
doi = "10.1208/pt0803069",
language = "English",
volume = "8",
pages = "E140--E144",
journal = "AAPS PharmSciTech",
issn = "1530-9932",
publisher = "American Association of Pharmaceutical Scientists",
number = "3",

}

RIS

TY - JOUR

T1 - Statistical evaluation of influence of viscosity and content of polymer on dipyridamole release from floating matrix tablets: a technical note

AU - Patel, Viralkumar

AU - Patel, Natavarlal M.

PY - 2007/9

Y1 - 2007/9

N2 - The present investigation described the influence of viscosity and content of HPMC on dipyridamole release using 32 full factorial design. All formulations had desired floating lag time (<2 minutes) regardless of viscosity and content of polymeric matrices. Results of multiple regression analysis indicate that both factors significantly affect the diffusion exponent (n), release rate constant (k), and percentage drug release at 1 hour, 4 hours, 6 hours, and 12 hour, (P<.05). Mechanism of drug release was found to be anomalous type to case-II transport depending upon the viscosity and content of polymer. It was found that content of HPMC had a dominant role in the initial phase of drug release, while in the later phase viscosity of HPMC Predominated

AB - The present investigation described the influence of viscosity and content of HPMC on dipyridamole release using 32 full factorial design. All formulations had desired floating lag time (<2 minutes) regardless of viscosity and content of polymeric matrices. Results of multiple regression analysis indicate that both factors significantly affect the diffusion exponent (n), release rate constant (k), and percentage drug release at 1 hour, 4 hours, 6 hours, and 12 hour, (P<.05). Mechanism of drug release was found to be anomalous type to case-II transport depending upon the viscosity and content of polymer. It was found that content of HPMC had a dominant role in the initial phase of drug release, while in the later phase viscosity of HPMC Predominated

KW - Diffusion

KW - Dipyridamole

KW - Methylcellulose

KW - Regression Analysis

KW - Solubility

KW - Tablets

KW - Viscosity

U2 - 10.1208/pt0803069

DO - 10.1208/pt0803069

M3 - Article

C2 - 17915819

VL - 8

SP - E140-E144

JO - AAPS PharmSciTech

JF - AAPS PharmSciTech

SN - 1530-9932

IS - 3

ER -