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Original languageEnglish
Number of pages15
Pages (from-to)170-184
JournalJournal of Pharmacy and Pharmacology
Journal publication date16 Feb 2016
Volume68
Issue2
Early online date11 Jan 2016
DOIs
StatePublished - 16 Feb 2016

Abstract

Objectives

Searching for chemicals that will safely enhance transdermal drug delivery is a significant challenge. This study applies support vector regression (SVR) for the first time to estimating the optimal formulation design of transdermal hydrocortisone formulations.

Methods

The aim of this study was to apply SVR methods with two different kernels in order to estimate the enhancement ratio of chemical enhancers of permeability.
Key findings

A statistically significant regression SVR model was developed. It was found that SVR with a nonlinear kernel provided the best estimate of the enhancement ratio for a chemical enhancer.

Conclusions

Support vector regression is a viable method to develop predictive models of biological processes, demonstrating improvements over other methods. In addition, the results of this study suggest that a global approach to modelling a biological process may not necessarily be the best method and that a ‘mixed-methods’ approach may be best in optimising predictive models.

Notes

This is the peer reviewed version of the following article: Shah, A., Sun, Y., Adams, R. G., Davey, N., Wilkinson, S. C. and Moss, G. P. (2016), Support vector regression to estimate the permeability enhancement of potential transdermal enhancers', Journal of Pharmacy and Pharmacology, Vol. 68 (2): 170–184, which has been published in final form at doi:10.1111/jphp.12508. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. © 2016 Royal Pharmaceutical Society.

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