University of Hertfordshire

Synaptic pathways in neural microcircuits

Research output: Contribution to journalReview article

  • Gilad Silberberg
  • Sten Grillner
  • Fiona E N LeBeau
  • Reinoud Maex
  • Henry Markram
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Original languageEnglish
Number of pages11
Pages (from-to)541-51
JournalTrends in neurosciences
Journal publication dateOct 2005
Publication statusPublished - Oct 2005


The functions performed by different neural microcircuits depend on the anatomical and physiological properties of the various synaptic pathways connecting neurons. Neural microcircuits across various species and brain regions are similar in terms of their repertoire of neurotransmitters, their synaptic kinetics, their short-term and long-term plasticity, and the target-specificity of their synaptic connections. However, microcircuits can be fundamentally different in terms of the precise recurrent design used to achieve a specific functionality. In this review, which is part of the TINS Microcircuits Special Feature, we compare the connectivity designs in spinal, hippocampal, neocortical and cerebellar microcircuits, and discuss the different computational challenges that each microcircuit faces.

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