University of Hertfordshire

From the same journal

By the same authors


  • Jatinder Bassin
  • Michelle Botha
  • Rajesh Garikipati
  • Madhu Goyal
  • Lee Martin
  • Amit Shah
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Original languageEnglish
Number of pages11
Pages (from-to)1-11
Journal publication date4 Nov 2017
Publication statusPublished - 4 Nov 2017


We have developed a simple and efficient synthetic route, starting from easily available starting materials, to the ring system benzo[4,5]isothiazolo[2,3-a]pyrazine-6,6-dioxide. A series of chalcones were synthesized which were subsequently reacted with chlorosulfonic acid to generate the chalcone sulphonyl chlorides. The chalcone sulphonyl chlorides were then treated with bromine to generate the dibromo chalcone sulphonyl chlorides. These were subsequently reacted with 1,2-diaminopropane and 2-methyl-1,2-diaminopropane in boiling ethanol resulting in compounds 2-10 and 11-19 respectively, in 12-80% yields. The products were characterized by spectral analysis and the definitive structure of compound 11 was determined by X-ray crystallography. The synthesized compounds were screened for potential antimicrobial properties against Bacillus subtilis, Escherichia coli, Proteus vulgaris and Staphylococcus aureus.


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