University of Hertfordshire

Tendon and Ligament Injuries in Elite Rugby: The Potential Genetic Influence

Research output: Contribution to journalReview article

Documents

  • Jon Brazier
  • M Antrobus
  • G Stebbings
  • S Day
  • S Heffernan
  • M Cross
  • A Williams
View graph of relations
Original languageEnglish
Article number138
Number of pages27
JournalSports
Journal publication date4 Jun 2019
Volume7
Issue6
DOIs
Publication statusPublished - 4 Jun 2019

Abstract

This article reviews tendon and ligament injury incidence and severity within elite rugby union and rugby league. Furthermore, it discusses the biological makeup of tendons and ligaments and how genetic variation may influence this and predisposition to injury. Elite rugby has one of the highest reported injury incidences of any professional sport. This is likely due to a combination of
well-established injury surveillance systems and the characteristics of the game, whereby high-impact body contact frequently occurs, in addition to the high intensity, multispeed and multidirectional nature of play. Some of the most severe of all these injuries are tendon and ligament/joint (non-bone),
and therefore, potentially the most debilitating to a player and playing squad across a season or World Cup competition. The aetiology of these injuries is highly multi-factorial, with a growing body of evidence suggesting that some of the inter-individual variability in injury susceptibility may be due to genetic variation. However, little effort has been devoted to the study of genetic
injury traits within rugby athletes. Due to a growing understanding of the molecular characteristics underpinning the aetiology of injury, investigating genetic variation within elite rugby is a viable and worthy proposition. Therefore, we propose several single nucleotide polymorphisms within candidate genes of interest; COL1A1, COL3A1, COL5A1, MIR608, MMP3, TIMP2, VEGFA, NID1 and
COLGALT1 warrant further study within elite rugby and other invasion sports.

ID: 16894854