University of Hertfordshire

The dual role of calcium in synaptic plasticity at the motor endplate

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Original languageEnglish
Title of host publicationComputational neuroscience: trends in research, 1997
EditorsJames M. Bower
Place of PublicationNEW YORK
PublisherPLENUM PRESS DIV PLENUM PUBLISHING CORP
Pages712
Number of pages6
ISBN (Print)0-306-45699-0, 978-0-306-45699-2
Publication statusPublished - 1997
EventProcs of the 5th Annual Computational Neuroscience Conference - Boston, United States
Duration: 14 Jul 199617 Jul 1996

Conference

ConferenceProcs of the 5th Annual Computational Neuroscience Conference
CountryUnited States
CityBoston
Period14/07/9617/07/96

Abstract

Focal blockade of postsynaptic acetylcholine receptors (AChRs) in a small region of the neuromuscular junction may cause long-term synapse elimination at that site. Blockade of the whole junction does not cause synapse loss, indicating that it is the contrast in postsynaptic activity between the blocked and unblocked regions which causes withdrawal of the synaptic terminals. This phenomenon can be explained by the dual role of calcium, both in controlling AChR gene transcription and influencing AChR aggregation. A computational model is provided and the stability of the solutions is confirmed by theoretical analysis and computer simulation.

Notes

Full text of this paper is not available in UHRA

ID: 381419