University of Hertfordshire

The effect of complex coordination on gallium determination using ion chromatography

Research output: Contribution to journalMeeting abstract

  • K. Staff
  • Marc Brown
  • S. A. Jones
  • P. Friden
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Original languageEnglish
Number of pages2
Pages (from-to)A31-A32
JournalJournal of Pharmacy and Pharmacology
Journal publication dateSep 2008
Volume60
IssueSupp 1
DOIs
Publication statusPublished - Sep 2008

Abstract

Interest in the therapeutic use of gallium is increasing due to the
discovery of its effectiveness as an anti-tumour and anti-microbial agent (Bernstein
1998). However, gallium strongly coordinates with many organic and inorganic
ligands and these complexes can display very different physico-chemical
properties (Houghton 1979). The gallium species present may also influence the
accuracy of the assay used to quantify it. To enable the design of dosage form
gallium must be accurately quantified irrespective of the coordination species
present. The aim of this study was to develop a simple, rapid method for
determining gallium content in a range of coordination complexes in a simple
vehicle and a biological matrix

ID: 627390