University of Hertfordshire

The effect of disulphide bond disruption on the barrier integrity of the human nail

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  • A. Baraldi
  • R.H. Khengar
  • S. Murdan
  • M.J. Traynor
  • S.A. Jones
  • Marc Brown
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Original languageEnglish
Title of host publicationAdvances in Dermatological Sciences
EditorsRobert Chilcott, Keith R. Brain
PublisherRoyal Society of Chemistry
Pages101-112
Number of pages12
Volume1
ISBN (Print)978-1849733984
DOIs
Publication statusPublished - 14 Apr 2014

Publication series

NameIssues in Toxicology
Number20

Abstract

Onychomycosis is the fungal infection of the nail and accounts for approximately 50% of all nail disorders [1]. The prevalence of onychomycosis is increasing and currently up to 10 % of people in the UK and US are reported to be affected by this condition [2,3]. It can be both physically and psychologically debilitating during the most progressive stages of the disease [4,5]. Fungi (most frequently Trichophyton rubrum and Trichophyton mentagrophytes), moulds (Scytalidium spp, Scopulariopsis spp, Fusarium spp, Acremonium spp, Onychocola canadensis) and yeasts (Candida spp) can be co-resident in a diseased nail and hence not every nail can be considered as being populated by the same community of species

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