University of Hertfordshire

  • Miguel Montenegro-Nicolini
  • Patricio E Reyes
  • Miguel O Jara
  • Parameswara R Vuddanda
  • Andrónico Neira-Carrillo
  • Nicole Butto
  • Sitaram Velaga
  • Javier O Morales
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Original languageEnglish
Number of pages12
Pages (from-to)3376-3387
JournalAAPS PharmSciTech
Journal publication date1 Nov 2018
Early online date22 Jun 2018
Publication statusPublished - 1 Nov 2018
Externally publishedYes


The buccal mucosa appears as a promissory route for biologic drug administration, and pharmaceutical films are flexible dosage forms that can be used in the buccal mucosa as drug delivery systems for either a local or systemic effect. Recently, thin films have been used as printing substrates to manufacture these dosage forms by inkjet printing. As such, it is necessary to investigate the effects of printing biologics on films as substrates in terms of their physical and mucoadhesive properties. Here, we explored solvent casting as a conventional method with two biocompatible polymers, hydroxypropyl methylcellulose, and chitosan, and we used electrospinning process as an electrospun film fabrication of polycaprolactone fibers due to its potential to elicit mucoadhesion. Lysozyme was used as biologic drug model and was formulated as a solution for printing by thermal inkjet printing. Films were characterized before and after printing by mechanical and mucoadhesive properties, surface, and ultrastructure morphology through scanning electron microscopy and solid state properties by thermal analysis. Although minor differences were detected in micrographs and thermograms in all polymeric films tested, neither mechanical nor mucoadhesive properties were affected by these differences. Thus, biologic drug printing on films was successful without affecting their mechanical or mucoadhesive properties. These results open way to explore biologics loading on buccal films by inkjet printing, and future efforts will include further in vitro and in vivo evaluations.

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