University of Hertfordshire

  • Tatjana Z. Verbic
  • Branko J. Drakulic
  • Mire Zloh
  • Ivan O. Juranic
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Original languageEnglish
Pages (from-to)692-699
Number of pages8
JournalLetters in Organic Chemistry
Volume5
Issue8
Publication statusPublished - Dec 2008

Abstract

Butanoic moiety of 4-aryl-2,4-dioxobutanoic acids is involved in interactions with metal ions within HIV-1 integrase active site. Sixteen congeneric 4-phenyl-2,4-dioxobutanoic acid derivatives with different substitution on the phenyl ring were prepared. Effects of substitution were studied by spectrometric methods (NMR, MS, UV/VIS) and linear free energy relationships. Better metal complexation ability of meta-alkyl substituted compounds, was observed. This observation might have pharmacological implications.

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