University of Hertfordshire

The efficacy of oral theophylline in ventilated premature infants

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Original languageEnglish
Pages (from-to)9-14
JournalEarly Human Development
Journal publication dateOct 1985
Publication statusPublished - Oct 1985


40 ventilated premature infants, with gestational ages of 24-34 weeks and a mean birthweight of 1422 g, were entered into a randomised controlled trial. 20 of the infants received orally 5 mg/ml anhydrous theophylline dissolved in 20% pure alcohol, with a loading dose of 5 mg/kg and then 1.25 mg/kg every 6 h. Plasma samples were assayed via an emit enzyme immunoassay, demonstrating satisfactory serum levels in all infants at 54 h after the loading dose. Possible side-effects were seen only in two infants, in one a tachycardia (220 beats/min) and the other became agitated during treatment

ID: 2097886