University of Hertfordshire

From the same journal

By the same authors

The role of microvesicles in cancer progression and drug resistance

Research output: Contribution to journalReview article

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Original languageEnglish
Number of pages6
Pages (from-to)293-8
JournalBiochemical Society Transactions
Journal publication date1 Feb 2013
Volume41
Issue1
DOIs
Publication statusPublished - 1 Feb 2013

Abstract

Microvesicles are shed constitutively, or upon activation, from both normal and malignant cells. The process is dependent on an increase in cytosolic Ca2+, which activates different enzymes, resulting in depolymerization of the actin cytoskeleton and release of the vesicles. Drug resistance can be defined as the ability of cancer cells to survive exposure to a wide range of anti-cancer drugs, and anti-tumour chemotherapeutic treatments are often impaired by innate or acquired MDR (multidrug resistance). Microvesicles released upon chemotherapeutic agents prevent the drugs from reaching their targets and also mediate intercellular transport of MDR proteins.

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