University of Hertfordshire

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Original languageEnglish
Article number208P
JournalpA2 online
Journal publication dateDec 2013
Volume11
Issue3
Publication statusPublished - Dec 2013
EventPharmacology 2013 [BPS Winter Meeting] - London, United Kingdom
Duration: 17 Dec 201319 Dec 2013

Abstract

Dysfunction of the lower urinary tract, such as urinary urgency and incontinence, characterised as bladder hyperreflexia, is a common non-motor feature of Parkinson’s disease (PD) (1). Previously, it was shown that common marmosets rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) also displayed bladder hyperreflexia (2) but the cause of this hyperreflexia has been attributed to central effects. To date no study has investigated whether there are any alterations in the parkinsonian bladder at the level of smooth muscle in primates. Here we compared the contractile responses of the detrusor strips from normal, drug naïve and animals that were previously MPTP treated (0.2mg/kg/day, s.c. for 5 consecutive days)

ID: 7545908