University of Hertfordshire

  • Kurinchi Gurusamy
  • Martine Walmsley
  • Brian R Davidson
  • Claire Frier
  • Barry Fuller
  • Steve Masson
  • Richard Morley
  • Ivana Safarik
  • Emmanouil Tsochatzis
  • Irfan Ahmed
  • Maxine Cowlin
  • John F Dillon
  • Graham Ellicott
  • Ahmed M Elsharkawy
  • Liz Farrington
  • Anthony Glachan
  • Nagappan Kumar
  • EJ Milne
  • Simon M Rushbrook
  • Amanda Smith
  • LIzzie Stafford
  • Andrew Yeoman
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Original languageEnglish
JournalBMJ Open
Journal publication date7 Feb 2019
Publication statusAccepted/In press - 7 Feb 2019


Objectives: There is a mismatch between research questions considered important by patients, carers, and healthcare professionals and the research performed in many fields of medicine. The Non-Alcohol-Related Liver and gallbladder disorders Priority setting partnership (NARLIP) was established to identify the top research priorities in the prevention, diagnostic, and treatment of gallbladder disorders and liver disorders not covered by the James-Lind Alliance (JLA) Alcohol-related liver disease (ARLD) Priority Setting Partnership.
Design: The methods broadly followed the principles of the JLA guidebook. The one major deviation from the JLA methodology was the final step of identifying priorities: instead of prioritisation by group discussions at a consensus workshop involving stakeholders, the prioritisation was achieved by a modified Delphi consensus process.
Results: A total of 428 unique valid diagnostic or treatment research questions were identified. A literature review established that none of these questions were considered ‘answered’ i.e. high quality systematic reviews suggest that further research is not required on the topic. The Delphi panel achieved consensus (at least 80% Delphi panel members agreed) that a research question was a top research priority for six questions. Four additional research questions with highest proportion of Delphi panel members ranking the question as highly important were added to constitute the top 10 research priorities.
Conclusions: A priority setting process involving patients, carers and healthcare professionals has been used to identify the top ten priority areas for research related to liver and gallbladder disorders. Basic, translational, clinical, and public health research are required to address these uncertainties.

ID: 16224005