University of Hertfordshire

  • M. Griffin (Inventor)
  • Russell J. Collighan (Inventor)
  • David Y.S. Chau (Inventor)
  • E. Verderio Edwards (Inventor)
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Original languageEnglish
Patent numberWO2006027622
Publication statusPublished - 16 Mar 2006


The present invention provides a method for producing an improved biomaterial comprising treating a collagen biomaterial with a transglutaminase under conditions which permit the formation of cross-links within the collagen. Preferably, the transglutaminase is a tissue transglutaminase, a plasma transglutaminase or a microbial transglutaminase. In a preferred embodiment, the collagen biomaterial further comprises a cell adhesion factor, such as fibronectin. The invention further provides biomaterials obtainable by the methods of the invention, and medical implants and wound dressings comprising the same

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