University of Hertfordshire

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Original languageEnglish
JournalJournal of Functional Foods
Journal publication date19 Aug 2018
StateSubmitted - 19 Aug 2018

Abstract

Montmorency Tart Cherries, MTC, (Prunus cerasus L.) possess a high anthocyanin content as well as one of the highest oxygen radical absorbance capacities fruits at common habitual portion sizes. MTC have been shown to contribute to reducing plasma lipids, plasma glucose and fat mass in rats and strikingly, similar effects are observed in humans. However, there is a paucity of research examining the molecular mechanisms by which such MTC effects are induced. Here, we show that when exposed to MTC, Caenorhabditis elegans display a significant extension to lifespan, and these worms are healthier. Using RNA interference, it is possible to silence genes involved in fat metabolism and provide insight into the molecular pathways through which MTC acts. We have identified that MTC functions via the PPAR signalling pathway, specifically nhr-49 and daf-22. Our data provides encouraging evidence that MTC may be operating as a calorie restrictive mimetic via metabolic pathways.

ID: 15324262