University of Hertfordshire

Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome

Research output: Contribution to journalReview article

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Original languageEnglish
Number of pages6
Pages (from-to)591-6
JournalRenal failure
Journal publication dateSep 2004
Volume26
Issue5
Publication statusPublished - Sep 2004

Abstract

We report a case of Waldenstrom's macroglobulinemia (WM) presenting as classic Goodpasture's syndrome. Thrombocytopenia, an additional autoimmune phenomenon, further complicated the clinical course. Renal disease is well recognized in Waldenstrom's macroglobulinemia and other B-cell dyscrasias. Similarly, a wide spectrum of autoimmune-mediated conditions has been reported in association with paraproteinemia. However, rapidly progressive glomerulonephritis in association with antiglomerular basement membrane antibodies has never been reported as either an autoimmune or a renal manifestation of WM. This article reviews the current understanding of renal pathology and autoimmune phenomenon associated with WM.

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