University of Hertfordshire

Weight regaining: From statistics and behaviors to physiology and metabolism

Research output: Contribution to journalReview article

  • Costas A. Anastasiou
  • Eleni Karfopoulou
  • Mary Yannakoulia
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Original languageEnglish
Number of pages13
Pages (from-to)1395-1407
JournalMetabolism: Clinical and Experimental
Journal publication date1 Nov 2015
Publication statusPublished - 1 Nov 2015
Externally publishedYes


Achieving maintenance of weight loss is crucial to combat obesity. However, most individuals tend to regain weight. Data from successful maintainers show that they remain vigilant and constantly apply techniques to oppose the course of regaining. On the other hand, current advances in obesity research show that the reduced obese state is a state of altered physiology in terms of energy balance. This review describes the physiological adaptations occurring after weight loss that predispose to regaining. Specifically, changes regarding body composition, hormonal background, energy expenditure and control of food intake are discussed. Moreover, metabolites that can act as regain predictors and dietary techniques to oppose regaining are presented.

ID: 13827056