Centre for Research in Mechanisms of Disease and Drug Discovery

Research output

Research output per year 1982 2005 2009 2011 2013 2014 2015 2016 2017 2020 2021 2023 2024

• 569 Article
• 39 Review article
• 30 Conference contribution
• 29 Poster
• 138 More
  • 28 Meeting abstract
  • 18 Special issue
  • 16 Chapter (peer-reviewed)
  • 15 Abstract
  • 8 Editorial
  • 8 Literature review
  • 8 Patent
  • 7 Presentation
  • 6 Doctoral Thesis
  • 5 Book
  • 4 Chapter
  • 4 Letter
  • 3 Working paper
  • 2 Paper
  • 2 Comment/debate
  • 2 Master's Thesis
  • 1 Other
  • 1 Other contribution

Research output per year

Research output per year

Search results

• 2023

  The neuroprotective properties of NLX-112 in MPTP treated mice are mediated by reactive gliosis and astrocytic GDNF

  Powell, W., Depoortere, R., Annett, L., Newman-Tancredi, A. & Iravani, M., 30 May 2023, (E-pub ahead of print) Brain and Neuroscience Advances: The International BNA 2023 Festival of Neuroscience. SAGE Publications, Vol. 7. 1 p. S_PZ3_063 (TP)

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access

  File

  • befiradol 100%
  • Glial Cell Line-Derived Neurotrophic Factor 63%
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine 61%
  • Gliosis 57%
  • Substantia Nigra 21%
  62 Downloads (Pure)

• Alpha7 nicotinic receptor- mediated reduction of L-DOPA-induced dyskinesia in 6OHDA rat model of Parkinson’s Disease

  Malekizadeh, Y., Hassankhani, K., Kingslake, A., Annett, L., Shoaib, M. & Iravani, M., 26 Apr 2023, Brain and Neuroscience Advances: The International BNA 2023 Festival of Neuroscience. SAGE Publications, Vol. 7. 1 p. M_PZ2_034 (TP)

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access

  File

  • 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea 100%
  • Dyskinesias 88%
  • Nicotinic Receptors 88%
  • Nicotine 79%
  • Parkinson Disease 67%
  15 Downloads (Pure)
• 2018

  Bioinformatics and Regression Analyses Manifest Tumor-Specific miRNA Expression Dynamics in Pediatric Embryonal Malignancies

  Braoudaki, M., Koutsouris, D-D., Kouris, I., Paidi, A., Koutsouri, G. & George Lambrou, I., 29 Oct 2018, 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). Institute of Electrical and Electronics Engineers (IEEE), p. 5834-5837 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access

  File

  • Pediatrics 100%
  • Bioinformatics 80%
  • Tumors 75%
  • Computational Biology 69%
  • MicroRNAs 62%
  1 Citation (Scopus)

  32 Downloads (Pure)

• Probiotics to prevent induction of Clostridium difficile infection?

  Etifa, P. & Baines, S., 12 Aug 2018, Probiotics to prevent induction of Clostridium difficile infection?.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Computational analysis of Gefitinib and methylated-hydroxypropylated cyclodextrin inclusion complexes for the treatment of childhood malignancies

  Hatziagapiou, K., Braoudaki, M., Bethanis, K., Yannakopoulou, K., Anastasiou, A., Koutsouri, G., Koutsouris, D. & Lambrou, G. I., 9 Apr 2018, 2018 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2018. Institute of Electrical and Electronics Engineers (IEEE), Vol. 2018-January. p. 194-197 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Cyclodextrins 100%
  • Gefitinib 75%
  • Pediatrics 23%
  • Assays 19%
  • Neoplasms 19%
• 2017

  Design, synthesis and in silico evaluation of small cationic peptides with potential antimicrobial activity

  Passarini, I., Rossiter, S., Malkinson, J. & Zloh, M., May 2017, 23rd Lakeland symposium on heterocyclic chemistry.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Identification and Validation of Mode of Action of Chalcones as Anti-Tubercular Compounds

  Anagani, B., Bassin, J., Cox, J., Besra, G., Benham, C. & Goyal, M., 25 Apr 2017, Identification and Validation of Mode of Action of Chalcones as Anti-Tubercular Compounds.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Mycolic Acid 100%
  • Antitubercular 83%
  • Chalcones 76%
  • Minimum Inhibitory Concentration 54%
  • Fatty Acid Methyl Ester 38%

• Synthesis, antimycobacterial activity evaluation and mode of action of series of novel diketones

  Singh, J., Rossiter, S., Bassin, J. & Goyal, M., 25 Apr 2017, Synthesis, antimycobacterial activity evaluation and mode of action of series of novel diketones.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Diketone 100%
  • Baker-Venkataraman Reaction 73%
  • Strain 57%
  • Acetophenones 53%
  • Benzoyl Chloride 51%

• Antimicrobial Properties of some African (Ghanaian) plants used in traditional/folk medicine for the topical treatment of infections

  Opoku Badu, C., Bassin, J. & Goyal, M., 2017, Antimicrobial Properties of some African (Ghanaian) plants used in traditional/folk medicine for the topical treatment of infections.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • disk diffusion antimicrobial test 100%
  • antimicrobial properties 91%
  • traditional medicine 86%
  • Alchornea cordifolia 76%
  • Klebsiella aerogenes 66%
• 2016

  In-silico investigation of RND efflux pumps in multi-drug resistance Gram negative bacteria

  Passarini, I., Rossiter, S., Tahmasi, T., Malkinson, J. & Zloh, M., Nov 2016, Plugging the antibiotics gap: a medicinal chemistry perspective.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Complex dynamics in tumor gene regulatory networks: Oncogenesis dynamics driven by “Genes Gone Crazy”

  Lambrou, G. I., Braoudaki, M., Katrakazas, P., Kouris, I., Iliopoulou, D., Koutsouri, T., Petropoulou, O. & Koutsouris, D. D., 17 Sept 2016, (E-pub ahead of print) XIV Mediterranean Conference on Medical and Biological Engineering and Computing, MEDICON 2016. Kyriacou, E., Christofides, S. & Pattichis, C. S. (eds.). Springer Nature Link, Vol. 57. p. 507-511

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Oncogenic 100%
  • Tumors 72%
  • Genes 67%
  • Aberrations 23%

• NMR and MD simulation studies of two cationic peptides with potential antimicorbial activity

  Passarini, I., Rossiter, S., Scott, M., Malkinson, J. & Zloh, M., Jul 2016, CCPN CCPBioSim joint conference.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Exploring the conformational space of cationic antimicrobial peptides

  Passarini, I., Rossiter, S., Malkinson, J. & Zloh, M., May 2016, RSC Chemical Biology and Bio-organic Chemistry postgraduate symposium.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Identification of new psychoactive substances using Raman spectroscopy: handheld and computational approaches.

  Guirguis, A., Kirton, S., Zloh, M., Samaras, E., Girotto, S., Berti, B. & Stair, J., May 2016, Identification of new psychoactive substances using Raman spectroscopy: : handheld and computational approaches. 3 ed. UK: Research and Advances in Psychiatry, Vol. 2. p. 94 1 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access

  File

  • Chemometrics 100%
  • Raman Spectroscopy 73%
  85 Downloads (Pure)

• TRPV4 dysfunction in endothelial cells from STZ treated rats reversed by insulin.

  Shamsaldeen, Y., Lione, L. & Benham, C., 17 Apr 2016, New Therapeutics for Diabetes and Obesity Keynote symposium, California.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Streptozocin 100%
  • Endothelial Cells 73%
  • Insulin 67%
  • Caveolin 1 48%
  • Calcium 34%

• Exploring the conformational space of cationic antimicrobial peptides

  Passarini, I., Rossiter, S., Zloh, M. & Malkinson, J., Apr 2016, 30th Molecular Modelling Workshop - Erlangen.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• 2015

  Decrease in TRPV4 Expression in Vascular Endothelium From STZ Treated Rats is Reversed by Insulin Treatment, (oral communication)

  Shamsaldeen, Y., Lione, L. & Benham, C., 17 Dec 2015, (Accepted/In press) pA2 online vol 13. p. 011P pA2 online vol 13 (3)

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Vascular Endothelium 100%
  • Streptozocin 90%
  • Vascular Smooth Muscle 88%
  • Smooth Muscle Myocytes 79%
  • Caveolin 1 78%

• Impairment in burrowing in the rat streptozocin (STZ) diabetes model of neuropathic pain and the benefits of social housing

  Fisher, A., Burnett, M., Pye, L., Upton, N. & Lione, L., 15 Jun 2015, NC3Rs/Society of Biology 3Rs Symposium, London.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Phenotypic evaluation of Clostridium difficile PCR ribotypes 078, 027, and 002: antimicrobial susceptibilities, cytotoxin production profiles, and biofilm formation.

  Baines, S. D., Wilcox, M. H., Graeme-Cook, K. & Keighley, D., 25 Apr 2015, 25th European Congress on Clinical Microbiology and Infectious Diseases (ECCMID)..

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  Open Access

  File

  • Clostridium difficile 100%
  • cytotoxins 97%
  • ribotypes 96%
  • biofilm 72%
  • anti-infective agents 54%
  315 Downloads (Pure)

• The ‘legal high’ dissociatives, diphenidine and methoxphenidine, have different effects on the rodent dopamine system.

  Dutta, N., Opacka-Juffry, J., Gant, A., Lione, L. & Davidson, C., 15 Apr 2015, Brain and Neuroscience Advances . Vol. P1-F-055 . p. P1-F-055

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • 1-(1-(2-methoxyphenyl)-2-phenylethyl)piperidine 100%
  • diphenidine 96%
  • Dopamine 38%
  • Rodentia 37%
  • Dopamine Plasma Membrane Transport Proteins 18%
• 2014

  Impairment in burrowing in the rat streptozocin (STZ) diabetes model of neuropathic pain and the benefits of social housing

  Burnett, M., Fisher, A., Pye, L., Upton, N. & Lione, L., Dec 2014, pA2 online. 3 ed. pA2 online, Vol. 12. p. 066P 12(3)

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • public housing 100%
  • streptozotocin 84%
  • burrowing 75%
  • diabetes 68%
  • pain 67%

• TRPV4 Dysfunction in Both Endothelial and Smooth Muscle Cells From Diabetic Rat Aorta

  Shamsaldeen, Y., Benham, C. & Lione, L., Dec 2014, pA2 online. 3 ed. Vol. 12. p. 212P

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Vasodilation 100%
  • Smooth Muscle Myocytes 91%
  • Aorta 90%
  • Vascular Smooth Muscle 84%
  • Transient Receptor Potential Channels 44%

• Contribution Of TRPA1 Agonist Actions Of Methylglyoxal To Colon Motility Dysfunction In Diabetes

  Assiri, A., Benham, S., Pritchard, S., Lione, L. & Benham, C., 2014, pA2 online. 3 ed. pA2 online, Vol. 12. p. 080P

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • electric field 100%
  • diabetes 97%
  • colon 90%
  • agonists 84%
  • carbachol 47%

• Effect of occlusion on the percutaneous absorption of aluminium from antiperspirant products

  Mistry, T., Staff, K., Anjum, K., Owen, J. D., Stair, J., Wilkinson, S. C. & Moss, G. P., 2014, Issues in Toxicology. p. 256-264 9 p. (Issues in Toxicology).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Effects of Methoxetamine in rat bladder and nucleus accumbens brain tissue. (abstract)

  Davidson, C., Hashomi, G., Gant, A., Fergus, S., Benham, C. & Lione, L., 2014, Res Advanced Psychiatry . Vol. 1:30.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone 100%
  • Nucleus Accumbens 55%
  • Dopamine 43%
  • Urinary Bladder 41%
  • Ketamine 28%

• Especificidad de tejido en la regulación transcripcional durante la germinación de semillas de Arabidopsis

  Barrero Sicilia, C., 2014, Fitohormonas: Metabolismo y Modo de Acción. p. 235-240

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• 2008

  El gen DOFG4 de Arabidopsis participa en la regulación de la germinación de la semilla mediada por ABA

  Barrero Sicilia, C., 2008, Fitohormonas: Metabolismo y Modo de Acción . p. 133-138

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• Modulación de la expresión por GA y ABA de los genes Ss1 y Ss2 que codifican sacarosa sintasa en cebada

  Barrero Sicilia, C., 2008, Fitohormonas: Metabolismo y Modo de Acción .

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• 1994

  Electrochemical detection of dopamine and nitric-oxide in-vitro and in rat corpus striatum: a study using fast cyclic voltammetry with a sinusoidal drive wave-form

  Iravani, M. M., Millar, J. & Kruk, Z. L., 1994, Monitoring Molecules in Neuroscience. Louilot, A., Durkin, T., Spampinato, U. & Cador, M. (eds.). TALENCE CEDEX: UNIV BORDEAUX I, LAB NEUROSCI COMPORTEMENTALES & COGNITIVES, p. 85-86 2 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• 1991

  Variations in evoked Dopamine overflow within the rat striatum measured using fast cyclic voltammetry

  Iravani, M. M. & Kruk, Z. L., 1991, Monitoring Molecules in Neuroscience: Proceedings of the 5th International Conference in Vivo Methods, 1992. Rollema, H., Westerink, B. H. C. & Drijfhout, W. J. (eds.). Groningen: UNIV CTR PHARMACY, p. 146-148 3 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution