Projects per year
Personal profile
Overview
Professor Young received undergraduate and medical training at Cambridge University & St Georges Hospital, London, qualifying in 1971. Specialist training in Rheumatology & a Research Fellowship in Immunology were based at Middlesex Hospital, London. Took up consultant post in Rheumatology at St Albans, Herts in 1982. Continued research interests in rheumatoid arthritis (RA), and instigated and became Chief Investigator of two longitudinal cohorts in RA from 1986.
Main research interest have been in the outcomes & prognostic factors of RA, based on two UK multicentre inception cohorts, the early RA Study (ERAS, 1986-1998, NIHR Portfolio study in follow up) and the Early RA Network (ERAN, 2002-present, in collaboration with MRC Clinical Trials Group). Funded by grants from Arthritis Research UK, BUPA Foundation, HealthCare Commission & the NIHR E&H CLRN. National & international collaborations have resulted in around 50 major publications in peer reviewed journals. Supervised 3 MDs, 3 PhDs, 3 MScs since 1990. Findings have been used for national standard setting in both British Society of Rheumatology (BSR) & National Institute of Clinical Excellence (NICE) guidelines on management of RA, the National Audit Office (NAO) report on RA, and in health economic analysis by NICE in appraisal of likely need and response to new biologic agents for RA.
Collaborated with researchers at University of Hertfordshire (UH) from 1995 which lead to a honorary academic post at UH and Postgraduate Medical School in 2009, and then a formal part time visiting professor post in 2012. This post involves maintaining and further developing the programme of original research and development in Rheumatology for Life & Medical Sciences and related disciplines:
- Leading funded research projects in collaboration with and support of colleagues within the local NHS and the University, in particular the Centre for Lifespan and Chronic Illness Research (CLiCIR), and other organisations
- Playing a leading role in the preparation of applications for grants from NIHR and other grant awarding bodies in association with colleagues from CLiCIR
- Submitting original articles for publication in high-impact peer-reviewed journals
- Playing a leading role in ensuring a high-quality submission involving the Postgraduate Medical School, CLiCIR and other members of the Health and Human Science Research Institute, in the 2014 Research Excellence Framework
- Developing links with the local NHS to promote engagement in Research and Development in Rheumatology within the locality
- Maintaining and further developing links with the Essex and Herts Clinical Research Network to promote engagement in Research and Development in Rheumatology within the locality
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Collaborations and top research areas from the last five years
Projects
- 3 Finished
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Risk Stratification in RA Patients with Multimorbidity
Wellsted, D. (PI) & Young, A. (CoI)
1/11/18 → 31/07/20
Project: Research
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MATURA
Young, A. (CoI), Carpenter, L. (CoI), Farrington, K. (PI) & Wellsted, D. (CoI)
1/03/16 → 1/10/18
Project: Other
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Analyse ERAS and ERAN dataset
Young, A. (PI)
Early Rheumatoid Arthritis Study (ERAS)
1/09/13 → 1/08/14
Project: Research
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Assessing 5-year radiographic progression in rheumatoid arthritis patients with moderate disease: findings from a uk multi-centre prospective observational study
Carpenter, L., Norton, S., Nikiphorou, E., Jayakumar, K., McWilliams, D., Dixey, J., Kiely, P., Walsh, D. & Young, A., 3 Jan 2025, (E-pub ahead of print) In: Annals of the Rheumatic Diseases. 76, p. 782 1 p., SAT0040.Research output: Contribution to journal › Meeting abstract › peer-review
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Defining a Process for the Development of a National Minimum Core Dataset (MCD) for Observational Cohort Studies in RA. A Multidisciplinary Exercise
Nikiphorou, E., Mackie, S. L., Morgan, A. & Young, A., 3 Jan 2025, (E-pub ahead of print) In: Annals of the Rheumatic Diseases. 73, Supplement 2, p. 337-338 2 p., THU0447.Research output: Contribution to journal › Article › peer-review
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Evidence That Both the Disease Course & Structural Outcomes in RA Have Become Less Severe over Time. A 25-Year Longitudinal Data Analysis Based on Two Consecutive UK Inception Cohorts
Nikiphorou, E., Norton, S., Carpenter, L., Dixey, J., Kiely, P., Walsh, D. & Young, A., 3 Jan 2025, (E-pub ahead of print) In: Annals of the Rheumatic Diseases. 73, Supplement 2, p. 125 1 p., OP0167.Research output: Contribution to journal › Article › peer-review
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Examining Baseline and 1 Year Predictors of Radiographic Progression over 5 Years Using Mixed Effects Negative Binomial Models: Results from the Early Rheumatoid Arthritis Study (ERAS) Cohort
Carpenter, L., Nikiphorou, E., Norton, S., Dixey, J. & Young, A., 3 Jan 2025, (E-pub ahead of print) In: Annals of the Rheumatic Diseases. 73, Supplement 2, p. 386 1 p., FRI0014.Research output: Contribution to journal › Article › peer-review
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FATIGUE: A PREVALENT AND PERSISTENT SYMPTOM IN EARLY RHEUMATOID ATHRITIS
Ifesemen, O., Mcwilliams, D., Young, A., Kiely, P. & Walsh, D., 3 Jan 2025, (E-pub ahead of print) In: Annals of the Rheumatic Diseases. 79, Supplement 1, p. 264 1 p., THU0100.Research output: Contribution to journal › Article › peer-review