Projects per year
My interests include existing and emergent food-borne pathogens, their prevalence and adaptations for survival during food production and processing. My research has also looked at using bacteriophages as possible means to control food-borne pathogens throughout food production.
As well as the practical uses of phage in the control of food-borne pathogens I am interested in their role in shaping bacterial communities. The description of phages as ‘the dark matter of the biosphere’ is quite compelling and it is only relatively recently that work to look at the metaviromes of the environment, animals and humans has become feasible. Bacterial communities are increasingly seen as pivotal to the understanding of health and disease progression or persistence, once again phage have profound effects on types and persistence of bacteria and it is clear that bacterial communities cannot meaningfully be studied without reference to the phages that share their environment.
Following from this, the increasing levels of antimicrobial resistance in human relevant pathogens is a serious problem. Recently there has been a revival in alternative therapies, including the use of bacteriophage in human therapies. More specifically this includes their use against organisms that are already resistant to existing therapeutically relevant antimicrobial compounds. Examining the possible synergies or antagonism of bacteriophage and antimicrobial chemotherapies is an emerging area of interest.
I also have interests in the presence and role of bacterial mutators in bacterial populations and their effects on the de novo development of antibiotic resistance, including the contributions of DNA damage and repair processes occurring in growing and 'stationary' cells.. This is also of relevance to development of microbial resistance to bacteriophages.
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31 March 2023: Identification, selection, characterization and optimisation of antimicrobial proteins from food insects and indigenous chickens’ skin and feathers as ingredients for food and industrial applications
1/10/22 → …
7/03/22 → 17/06/22
Functionalised Copper Nanoparticles with Gold Nanoclusters Part I. Highly Selective Electrosynthesis of Hydrogen Peroxide (H2O2): Part I. Highly Selective Electrosynthesis of Hydrogen Peroxide (H2O2)Kun Luo, Tong Liu, and Xiangqun Zhuge, Simon Paul Graham, Ren, G., Chung, E. & Timms, A. R., 5 Aug 2023, (Submitted) In: ACS Omega. p. 1-15 15 p.
Research output: Contribution to journal › Article › peer-review
Non-Toxigenic Clostridioides difficile Strain E4 (NTCD-E4) Prevents Establishment of Primary C. difficile Infection by Epidemic PCR Ribotype 027 in an In Vitro Human Gut ModelEtifa, P., Rodríguez, C., Harmanus, C., Sanders, I. M. J. G., Sidorov, I. A., Mohammed, O. A., Savage, E., Timms, A. R., Freeman, J., Smits, W. K., Wilcox, M. H., Baines, S. D., Monchi, M. (ed.), Samarkos, M. (ed.) & Di Bella, S. (ed.), 22 Feb 2023, (E-pub ahead of print) In: Antibiotics. 12, 3, 15 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile5 Downloads (Pure)
Proceedings of Abstracts, School of Physics, Engineering and Computer Science Research Conference 2022Coudron, L. (ed.), Amafabia, D., Asimea, L., Bally, J., Baran, A., Boies, A., Borjali, A., Bosomworth, C., Burningham, B., Chaliasou, N-A., CHEN, Y. K., Cheong, Y. K., Chizari, M., Chung, E., Coppin, K., David-West, O., Dennler, N., Dhakal, H., Dimov, N., Dmitruk, E., & 98 others, 4 Nov 2022, University of Hertfordshire. 128 p.
Research output: Book/Report › AnthologyOpen AccessFile76 Downloads (Pure)
Hooton, S. P. T., Timms, A. R., Cummings, N. J., Moreton, J., Wilson, R. & Connerton, I. F., 1 Nov 2014, In: Plasmid. 76, p. 32-39 8 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access14 Citations (Scopus)
Javed, M. A., Ackermann, H-W., Azeredo, J., Carvalho, C. M., Connerton, I., Evoy, S., Hammerl, J. A., Hertwig, S., Lavigne, R., Singh, A., Szymanski, C. M., Timms, A. & Kropinski, A. M., 1 Jan 2014, In: Archives of Virology. 159, 1, p. 181-90 10 p.
Research output: Contribution to journal › Article › peer-review39 Citations (Scopus)