Projects per year
Personal profile
Research interests
Chris Benham is an electrophysiologist with 18 years experience working in R&D in the pharmaceutical industry. His early academic interests were in the cardiovascular area, and this broadened to ion channel drug discovery in the CNS with a continuing focus on calcium permeable ion channels. At GSK he was instrumental in setting up and developing the companies interest in the TRP family of ion channels.
The current focus of Dr Benham’s research continues this interest and is examining the function of TRP family members in sensory systems, the cardiovascular system and the gastrointestinal tract with a number of collaborators including GSK. There is a particular focus on TRP channel dysfunction in disease.
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Projects
- 5 Finished
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Exploring the therapeutic potential of TRPV1 antagonism in diabetes without hyperthermia
Lione, L. (PI), Benham, C. (PI) & Pritchard, S. (PI)
7/06/17 → 25/07/17
Project: Research
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Characterisation of the inflammatory response induced by viral and bacterial challenge in models of persistent and resolved pulmonary inflammation
Lione, L. (PI), Benham, C. (PI) & Uddin, S. (Researcher)
2/09/13 → 26/03/18
Project: Research
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KetBladd: Mechanism of action of ketamine induced bladder hypersensitivity
Lione, L. (PI), Gant, A. (Researcher), Benham, C. (PI) & Fergus, S. (PI)
30/07/12 → 31/12/18
Project: Other
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Thomas (Tom) B. Bolton – a major force in smooth muscle research
Zholos, A. V., Greenwood, I. A., Lang, R. J., Benham, C. D., Aaronson, P. I., Garland, C. J., Weston, A. H., Prestwich, S. A., Gordienko, D. V., Povstyan, O. V., Zhang, H., Clapp, L. H., Pucovsky, V., Tare, M., Fenech, C. J., Unno, T., Muraki, K., Shi, J., Hughes, A. D. & Halstead, T. K. & 1 others, , 1 Aug 2024, In: Journal of Physiology. 602, 15, p. 3601-3604 4 p.Research output: Contribution to journal › Article › peer-review
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Dysregulation of TRPV4, eNOS and caveolin-1 contribute to endothelial dysfunction in the streptozotocin rat model of diabetes
Shamsaldeen, Y., Lione, L. & Benham, C., 5 Dec 2020, In: European Journal of Pharmacology. 888, 173441, EJP-54180R2.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)31 Downloads (Pure) -
FUNCTIONAL AND HISTOLOGICAL CHANGES IN RAT URINARY BLADDER FOLLOWING SHORT AND LONG TERM KETAMINE EXPOSURE
Gant, A., Fergus, S., Benham, C. & Lione, L., 18 Nov 2020.Research output: Contribution to conference › Presentation › peer-review
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Identification and validation of the mode of action of the chalcone anti-mycobacterial compounds
Anagani, B., Singh, J., Bassin, J., Besra, G., Benham, C., Reddy, T. R. K., Cox, J. & Goyal, M., 18 May 2020, (E-pub ahead of print) In: The Cell Surface. 6, 100041.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)64 Downloads (Pure) -
Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1 and endothelial dysfunction in streptozotocin treated rats: Supplement to Diabetes Metab Res Rev. 34(5):e2995.
Lione, L., Benham, C. & Shamsaldeen, Y., 13 Aug 2019, Biomedical Advances .Research output: Other contribution
Open AccessFile58 Downloads (Pure)