Projects per year
Chris Benham is an electrophysiologist with 18 years experience working in R&D in the pharmaceutical industry. His early academic interests were in the cardiovascular area, and this broadened to ion channel drug discovery in the CNS with a continuing focus on calcium permeable ion channels. At GSK he was instrumental in setting up and developing the companies interest in the TRP family of ion channels.
The current focus of Dr Benham’s research continues this interest and is examining the function of TRP family members in sensory systems, the cardiovascular system and the gastrointestinal tract with a number of collaborators including GSK. There is a particular focus on TRP channel dysfunction in disease.
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- 5 Finished
Exploring the therapeutic potential of TRPV1 antagonism in diabetes without hyperthermia
Lione, L., Benham, C. & Pritchard, S.
7/06/17 → 25/07/17
Characterisation of the inflammatory response induced by viral and bacterial challenge in models of persistent and resolved pulmonary inflammation
Lione, L., Benham, C. & Uddin, S.
2/09/13 → 26/03/18
KetBladd: Mechanism of action of ketamine induced bladder hypersensitivity
Lione, L., Gant, A., Benham, C. & Fergus, S.
30/07/12 → 31/12/18
Innervated trigeminal neurones
Benham, C. & Molleman, A.
1/10/08 → 30/09/11
Summer Vacation Studentship
1/07/08 → 31/08/08
Dysregulation of TRPV4, eNOS and caveolin-1 contribute to endothelial dysfunction in the streptozotocin rat model of diabetesShamsaldeen, Y., Lione, L. & Benham, C., 5 Dec 2020, In: European Journal of Pharmacology. 888, 173441, EJP-54180R2.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Citations (Scopus)10 Downloads (Pure)
FUNCTIONAL AND HISTOLOGICAL CHANGES IN RAT URINARY BLADDER FOLLOWING SHORT AND LONG TERM KETAMINE EXPOSUREGant, A., Fergus, S., Benham, C. & Lione, L., 18 Nov 2020.
Research output: Contribution to conference › Presentation › peer-review
Identification and validation of the mode of action of the chalcone anti-mycobacterial compoundsAnagani, B., Singh, J., Bassin, J., Besra, G., Benham, C., Reddy, T. R. K., Cox, J. & Goyal, M., 18 May 2020, (E-pub ahead of print) In: The Cell Surface. 6, 100041.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile1 Citation (Scopus)42 Downloads (Pure)
Diabetic dyslipidaemia is associated with alterations in eNOS, caveolin-1 and endothelial dysfunction in streptozotocin treated rats: Supplement to Diabetes Metab Res Rev. 34(5):e2995.Lione, L., Benham, C. & Shamsaldeen, Y., 13 Aug 2019, Biomedical Advances .
Research output: Other contributionOpen AccessFile22 Downloads (Pure)
Contractile dysfunction and nitrergic dysregulation in small intestine of a primate model of Parkinson’s disease: contractile dysfunction in MPTP-treated primate ileumColetto, E., Dolan, J. S., Pritchard, S., Gant, A., Hikima, A., Jackson, M. J., Benham, C., Chaudhuri, K. R., Rose, S., Jenner, P. & Iravani, M., 10 Jun 2019, In: npj Parkinson's Disease. 5, 10, p. 1-12 12 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile6 Citations (Scopus)16 Downloads (Pure)