Personal profile
Overview
Dr David Prowse is a Cell and Molecular Biologist specialising in Cancer Biology, who has 25 years of experience working and teaching in the area of cancer research in the UK and USA. His early academic interest was in the biology of gap junctions, and this broadened to regulation of epithelial differentiation and stem cells, cancer development and progression, and the role of cancer stem cells. The recent focus of Dr Prowse’s research has been on prostate and skin cancer, and has two main aims: (a) to identify and characterize genes contributing to the development and progression of cancer, focusing on the role of signalling pathways, cancer stem cells and the process leading to androgen independent prostate cancer; (b) to determine the contribution of human papillomavirus (HPV) to the development of skin cancers. Dr Prowse has contributed to research published in a range of Journals including: British Journal of Dermatology, Cancer Cell International, Cell Research, Current Biology, Development, Developmental Biology, Developmental Cell, Experimental Dermatology, Histopathology, Journal of Biological Chemistry, Journal of Cell Science, Nature, Pathology and PLoS One.
Research interests
- Biosciences
- Cancer
- Cell Signalling
- Circulating Tumour Cells
- Educational Research
- Human Papillomavirus
- Stem Cells
Teaching specialisms
- Biomedical Science
- Biosciences
- Cancer Biology
- Cell Biology
- Genetics and Gene Expression
- Molecular Biology
- Problem Based Learning (PBL)
- Stem Cell Biology
Education/Academic qualification
Education, Postgraduate Certificate in Academic Practice, HEI: Queen Mary University of London
Award Date: 3 Nov 2011
Cancer Biology, PhD, Specificity of Gap Junctional Communication, HEI: The University of Glasgow
Award Date: 4 Dec 1993
Applied Biology, BSc(2:1 Hons), HEI: The University of Bath
Award Date: 19 Jun 1989
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Research output
- 27 Article
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Gli1 confers profound phenotypic changes upon lncap prostate cancer cells that include the acquisition of a hormone independent state
Nadendla, S. K., Hazan, A., Ward, M., Harper, L. J., Moutasim, K., Bianchi, L. S., Naase, M., Ghali, L., Thomas, G. J., Prowse, D. M., Philpott, M. P. & Neill, G. W., 30 May 2011, In: PLoS ONE. 6, 5, e20271.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)140 Downloads (Pure) -
Alternative HER/PTEN/Akt pathway activation in HPV positive and negative penile carcinomas
Stankiewicz, E., Prowse, D. M., Ng, M., Cuzick, J., Mesher, D., Hiscock, F., Lu, Y. J., Watkin, N., Corbishley, C., Lam, W. & Berney, D. M., 10 Mar 2011, In: PLoS ONE. 6, 3, e17517.Research output: Contribution to journal › Article › peer-review
Open AccessFile84 Citations (Scopus)206 Downloads (Pure) -
The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma
Stankiewicz, E., Prowse, D. M., Ktori, E., Cuzick, J., Ambroisine, L., Zhang, X., Kudahetti, S., Watkin, N., Corbishley, C. & Berney, D. M., 1 Feb 2011, In: Histopathology. 58, 3, p. 433-439 7 p.Research output: Contribution to journal › Article › peer-review
File26 Citations (Scopus)275 Downloads (Pure) -
Immunohistochemistry for p16, but not Rb or p21, is an independent predictor of prognosis in conservatively treated, clinically localised prostate cancer
Kudahetti, S. C., Fisher, G., Ambroisine, L., Prowse, D. M., Kattan, M. W., Foster, C. S., Møller, H., Oliver, T., Fletcher, A., Cooper, C., Reuter, V., Scardino, P., Cuzick, J. & Berney, D. M., 1 Oct 2010, In: Pathology. 42, 6, p. 519-523 5 p.Research output: Contribution to journal › Article › peer-review
File19 Citations (Scopus)203 Downloads (Pure) -
Human papillomavirus is detected in transitional cell carcinoma arising in renal transplant recipients
Husain, E., Prowse, D. M., Ktori, E., Shaikh, T., Yaqoob, M., Junaid, I. & Baithun, S., 9 Nov 2009, In: Pathology. 41, 3, p. 245-247 3 p.Research output: Contribution to journal › Article › peer-review
File17 Citations (Scopus)196 Downloads (Pure)