Projects per year
Personal profile
Overview
Mahmoud Iravani has a long standing research interest in neurodegeneration mechanisms in Parkinson’s Disease and L-Dopa induced dyskinesia. He has invetigated the anti-apoptotic and anti-aggregative role of novel agents in various models of Parkinson’s disease. At the University of Herfordshire his focus has been primarily on Parkinson’s disease neuropathology as well as novel treatments for L-dopa induced dyskinesia. Specifically, he also has focussed on the non-dopaminergic aspects of the parkinsonian pathology and role of inflammation in protein aggregation and the treatment of of l-dopa induced dyskinesia.
Research interests
Neurodegeneration in Parkinson's disease
Role of antidyskinetic agents in the treatment of L-DOPA induced dyskinesia
Role of inflammation in neurodegenerative processes
Role of intracellular protein aggregation in neurodegneration
Non-dopaminergic dysfunction in Parkinson's disease: dysautonomia
Education/Academic qualification
Pharmacology, PhD, Physiological and Pharmacological Profile of Neuropeptide Y in autonomically innervated organs, HEI: Newcastle University
Award Date: 11 Apr 1990
External positions
visiting Lecturer, HEI: King's College London
1 Oct 2009 → Aug 2019
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Collaborations and top research areas from the last five years
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PRONET at UH: Parkinson's Research Outreach Network at the University of Hertfordshire
Annett, L. (PI), Hadley, R. (PI), Iravani, M. (PI) & Yousif, N. (PI)
10/04/24 → …
Project: Research
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Evaluation of nicotine and its analogues to remediate dyskinesias and cognitive deficits associated with Parkinson's disease
Iravani, M. (PI)
27/08/19 → 28/10/22
Project: Research
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Evaluation of nicotine and its analogues to remediate dyskinesias and cognitive deficits associated with Parkinson's disease
Iravani, M. (PI)
27/08/19 → 26/08/21
Project: Other
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Neuroprotective properties of serotonin 5-HT1A receptor agonists in models of Parkinson’s disease
Iravani, M. (PI)
1/10/18 → 31/12/22
Project: Other
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Mechanisms underlying the onset and expression of levodopa-induced dyskinesia and their pharmacological manipulation
Iravani, M. M. & Jenner, P., Dec 2011, In: Journal of Neural Transmission. 118, 12, p. 1661-1690 30 p.Research output: Contribution to journal › Literature review › peer-review
64 Citations (Scopus) -
Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration
Iravani, M. M., Kashefi, K., Mander, P., Rose, S. & Jenner, P., Mar 2002, In: Neuroscience. 110, 1, p. 49-58 10 p.Research output: Contribution to journal › Article › peer-review
220 Citations (Scopus) -
3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates
Iravani, M. M., Jackson, M. J., Kuoppamaki, M., Smith, L. A. & Jenner, P., 8 Oct 2003, In: Journal of Neuroscience. 23, 27, p. 9107-9115 9 p.Research output: Contribution to journal › Article › peer-review
82 Citations (Scopus) -
Unilateral pallidotomy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets exhibiting levodopa-induced dyskinesia
Iravani, M. M., Costa, S., Al-Bargouthy, G., Jackson, M. J., Zeng, B.-Y., Kuoppamaki, M., Obeso, J. A. & Jenner, P., Sept 2005, In: European Journal of Neuroscience. 22, 6, p. 1305-1318 14 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Lipopolysaccharide-induced nigral inflammation leads to increased IL-1β tissue content and expression of astrocytic glial cell line-derived neurotrophic factor.
Iravani, M. M., Sadeghian, M., Leung, C. C. M., Jenner, P. & Rose, S., 29 Feb 2012, In: Neuroscience Letters. 510, 2, p. 138-142 5 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus)