Projects per year
Personal profile
Research interests
Microbes evolve rapidly to survive in challenging environments, including exposure to antimicrobials. The emergence of antibiotic resistance in bacteria, particularly pathogens with potential to infect both humans and animals (e.g. Clostridium difficile, MRSA, Escherichia coli, and Mycobacterium bovis), require investigations into alternative antimicrobials.
My research uses gene silencing agents, cationic peptides, and phage as antimicrobials and genetic tools for finding good drug targets. Related to the control of antibiotic resistance is understanding the transmission of antibiotic resistance genes within bacterial communities. My research is focused on how C. difficile phages contribute to horizontal gene transfer and whether such activities preclude their use as antimicrobials.
Another strategy for infection control is to prime host immune responses using vaccines. Part of my research is on developing subunit vaccines against Theileria lestoquardi and T. parva, which are important protozoan parasites infecting and killing cattle in developing countries.
Overview
Dr Shan Goh is a Senior Lecturer in Microbiology. She completed her BSc(Hons.) in Microbiology and Pathology at the University of Western Australia, where she continued postgraduate studies on bacteriophages of Clostridium difficile obtaining her PhD in 2004. Dr Goh was a postdoctoral researcher at the National University of Singapore, studying C. difficile phages, from 2004-2006. She then joined the Bioprocessing Technology Institute, Singapore as a Research Scientist constructing expression plasmids for metabolic engineering.
In 2006, she was awarded a visiting scientist scholarship by the Swedish Institute for postdoctoral training at Karolinska Institute in Stockholm, Sweden. Here Dr Goh investigated growth essential gene stringency and thereafter joined a team searching for novel human viruses using next generation sequencing. Dr Goh moved to the Royal Veterinary College in 2009, working as a postdoctoral scientist formulating novel molecular therapeutics targeting pathogens infecting humans and animals.
In 2017, Dr Goh joined the University of Hertfordshire and plans to continue her research on antimicrobial strategies, phage-mediated gene transfer, and genetic tool development in microbes important in human and animal health.
Students interested in working with Dr Goh should contact her directly via email <s.goh5@herts.ac.uk>. More information on postgraduate studies in Microbiology at UH may be found here:
https://www.herts.ac.uk/courses/masters-by-researchphd-microbiology
Education/Academic qualification
Microbiology, PhD, University of Western Australia
3 Jan 2000 → 15 Dec 2003
Award Date: 28 Jun 2004
Microbiology and Pathology, BSc (Hons.) 1st Class, University of Western Australia
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Network
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MRC mid-range equipment full application - Anaerobic workstation
Project: Research
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Targeting intracellular dermatology pathogens by combining phage and nano-technologies
6/06/22 → 23/12/22
Project: Research
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Membrane vesicle-mediated sensitization of Clostridioides difficile to phage infection
1/03/21 → 31/08/22
Project: Other
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Editorial: Microbial interactions of Clostridioides difficile
Goh, S., Mullany, P. & Riley, T. V., 6 Jan 2023, (E-pub ahead of print) In: Frontiers in Microbiology. 13, 2 p.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile -
Molecular basis for DarT ADP-ribosylation of a DNA base
Schuller, M., Butler, R., Ariza, A., Tromans-Coia, C., Jankevicius, G., Claridge, T., Kendall, S., Goh, S., Stewart, G. & Ahel, I., 18 Aug 2021, In: Nature.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
Development of a Potential Yeast-Based Vaccine Platform for Theileria parva Infection in Cattle
Goh, S., Kolakowski, J., Holder, A., Pfuhl, M., Ngugi, D., Ballingall, K., Tombacz, K. & Werling, D., 8 Jul 2021, In: Frontiers in Immunology. 12, July 2021, 18 p., 674484.Research output: Contribution to journal › Article › peer-review
Open AccessFile52 Downloads (Pure) -
Re-sensitization of Mycobacterium smegmatis to Rifampicin Using CRISPR Interference Demonstrates Its Utility for the Study of Non-essential Drug Resistance Traits
Faulkner, V., Cox, A., Goh, S., van Bohemen, A., Gibson, A., Liebster, O., Wren, B., Willcocks, S. & Kendall, S., 1 Feb 2021, In: Frontiers in Microbiology. 11, 10 p., 619427.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Downloads (Pure) -
The development of species-specific antisense peptide nucleic acid method for the treatment and detection of viable Salmonella
Adebowale, O., Goh, S. & Good, L., Jun 2020, In: Heliyon. 6, 6, 9 p., e04110.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)16 Downloads (Pure)