Projects per year
Personal profile
Research interests
Microbes evolve rapidly to survive in challenging environments, including exposure to antimicrobials. The emergence of antibiotic resistance in bacteria, particularly pathogens with potential to infect both humans and animals (e.g. Clostridium difficile, MRSA, Escherichia coli, and Mycobacterium bovis), require investigations into alternative antimicrobials.
My research uses gene silencing agents, cationic peptides, and phage as antimicrobials and genetic tools for finding good drug targets. Related to the control of antimicrobial resistance (AMR) is understanding the transmission of resistance genes within bacterial communities, e.g. by phages and extracellular vesicles.
I am also interested in AMR from a One Health context. In particular, in C. difficile and Staphylococci evolution, emergence, persistence and transmission between humans, animals, and the environment.
Overview
Dr Shan Goh is a Senior Lecturer in Microbiology. She completed her BSc(Hons.) in Microbiology and Pathology at the University of Western Australia, where she continued postgraduate studies on bacteriophages of Clostridium difficile obtaining her PhD in 2004. Dr Goh was a postdoctoral researcher at the National University of Singapore, studying C. difficile phages, from 2004-2006. She then joined the Bioprocessing Technology Institute, Singapore as a Research Scientist constructing expression plasmids for metabolic engineering.
In 2006, she was awarded a visiting scientist scholarship by the Swedish Institute for postdoctoral training at Karolinska Institute in Stockholm, Sweden. Here Dr Goh investigated growth essential gene stringency and thereafter joined a team searching for novel human viruses using next generation sequencing. Dr Goh moved to the Royal Veterinary College in 2009, working as a postdoctoral scientist formulating novel molecular therapeutics targeting pathogens infecting humans and animals.
In 2017, Dr Goh joined the University of Hertfordshire continues her research on antimicrobial strategies and horizontal gene transfer in microbes important in human and animal health.
Students interested in working with Dr Goh should contact her directly via email <[email protected]>. More information on postgraduate studies in Microbiology at UH may be found here:
https://www.herts.ac.uk/courses/masters-by-researchphd-microbiology
Education/Academic qualification
Microbiology, PhD, Phenotypic and genotypic characterisation of bacteriophages of Clostridium difficile, University of Western Australia
3 Jan 2000 → 15 Dec 2003
Award Date: 28 Jun 2004
Microbiology and Pathology, BSc (Hons.) 1st Class, University of Western Australia
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Collaborations and top research areas from the last five years
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Furthering collaborative action for pork safety (F-CAPS) - Phase 2
Goh, S. (PI)
UK Food Safety Research Network
1/07/24 → 31/03/25
Project: Research
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Bacteriophages against surgical site infections
Goh, S. (PI) & McAuley, L. (CoPI)
1/11/23 → 30/04/26
Project: Research
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Clostridioides difficile in UK pigs and risks to the food chain (Phase 2)
Goh, S. (PI) & Baines, S. (CoI)
4/09/23 → 3/09/27
Project: Research
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KE-CAPS: Knowledge exchange in Collaborative action for Pork Safety (KE-CAPS)
Goh, S. (PI)
UK Food Safety Research Network
11/03/24 → 10/09/24
Project: Research
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Removal of mobile genetic elements from the genome of Clostridioides difficile and the implications for the organism’s biology
Hussain, H., Nubgan, A., Rodríguez, C., Imwattana, K., Knight, D., Parthala, V., Mullany, P. & Goh, S., 20 Jun 2024, In: Frontiers in Microbiology. 15, p. 1-15 15 p., 1416665.Research output: Contribution to journal › Article › peer-review
Open AccessFile29 Downloads (Pure) -
Membrane vesicles of Clostridioides difficile and other Clostridial species
Goh, S. & Inal, J., 5 Jan 2024, Updates on Clostridioides difficile in Europe: Advances in Microbiology, Infectious Diseases and Public Health. 2 ed. Switzerland: Springer Nature , Vol. 18. p. 315-327 13 p. (Advances in Experimental Medicine and Biology; vol. 1435).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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Editorial: Microbial interactions of Clostridioides difficile
Goh, S., Mullany, P. & Riley, T. V., 6 Jan 2023, In: Frontiers in Microbiology. 13, p. 1-2 2 p., 1129416.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile11 Downloads (Pure) -
Molecular basis for DarT ADP-ribosylation of a DNA base
Schuller, M., Butler, R., Ariza, A., Tromans-Coia, C., Jankevicius, G., Claridge, T., Kendall, S., Goh, S., Stewart, G. & Ahel, I., 26 Aug 2021, In: Nature. 596, 7873, p. 597-602 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Downloads (Pure) -
Development of a Potential Yeast-Based Vaccine Platform for Theileria parva Infection in Cattle
Goh, S., Kolakowski, J., Holder, A., Pfuhl, M., Ngugi, D., Ballingall, K., Tombacz, K. & Werling, D., 8 Jul 2021, In: Frontiers in Immunology. 12, July 2021, p. 674484 18 p., 674484.Research output: Contribution to journal › Article › peer-review
Open AccessFile71 Downloads (Pure)