Projects per year
Personal profile
Overview
Sharon is the Head of the new provisional Centre for Research in Mechanisms of Disease and Drug Design, in the School of Life and Medical Sciences. The Centre integrates the university's scientific expertise in the understanding of health and disease, and the design of new therapeutic strategies.
Sharon is a synthetic and medicinal chemist, with extensive research experience in the development of novel small molecules applied to understanding and treating disease.
Sharon obtained her PhD in the synthesis of natural product analogues to treat parasitic diseases, followed by postdoctoral experience in the areas of cancer pro-drug design and cardiovascular mechanisms, before joining the University in 2005.
Research interests
Medicinal and biological chemistry, drug design and synthesis. Cancer drug targets and drug design. Antiobiotic-restoring peptides to combat antimicrobial resistance. Natural product analogues with anti-inflammatory properties. Small molecule cardiovascular system probes. Novel synthetic technologies.
Teaching specialisms
Organic and medicinal chemistry. Integration of science and clinical aspects of pharmacy; relating structure and functions of medicines to their clinical use.
Education/Academic qualification
Chemistry, BSc, HEI: King's College London
PhD, Synthesis of quinolines with anthelmintic activity, HEI: King's College London
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Collaborations and top research areas from the last five years
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In Silico Design and Synthetic Planning of Novel METTL3 Inhibitors for High- Risk Neuroblastoma
Ostovar, M. (PI), Rossiter, S. (CoI) & Botha, M. (CoI)
5/01/26 → 4/01/27
Project: Research
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Ligand-protein studies for development of inhibitors of S100P, as a potential novel therapy for pancreatic cancer
Rossiter, S. (PI), Kirton, S. (CoI) & Hyvönen, M. (CoI)
1/04/18 → 31/12/19
Project: Other
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Ligand-protein studies for development of inhibitors of S100P
Rossiter, S. (PI), Kirton, S. (PI) & Hyvönen, M. (PI)
1/01/18 → 31/12/19
Project: Research
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Mechanisms of anti-diabetic actions of natural plant products
Lione, L. (PI), Mackenzie, L. S. (PI), Rossiter, S. (PI), Bading, B. (Researcher) & De Souza, A. (PI)
3/03/14 → 31/07/18
Project: Research
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Design of inhibitors of S100P, a protein implicated in pancreatic cancer progression
Rossiter, S. (PI), Cheng, W. P. (CoI) & Kirton, S. (CoI)
Association for International Cancer Research (AICR)
1/01/13 → 31/12/16
Project: Research
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A green-solvent toolbox for medicinally privileged scaffolds
Lockhart, J., Ahmeti, E., Rossiter, S., Jeramaz, L., Afshari, S., Azizi, H. & Ostovar, M., 2026, (In preparation) In: SynLett.Research output: Contribution to journal › Article
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Bicyclic 6-6 Systems: Pteridines
Rossiter, S. & Ostovar, M., 2022, Comprehensive Heterocyclic Chemistry IV. Elsevier, Vol. 10. p. 796-855Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open AccessFile4 Citations (Scopus)943 Downloads (Pure) -
Synthesis and in silico modelling of the potential dual mechanistic activity of small cationic peptides potentiating the antibiotic novobiocin against susceptible and multi-drug resistant Escherichia coli
Passarini, I., Ernesto de Resende, P., Soares, S., Tahmasi, T., Stapleton, P., Malkinson, J., Zloh, M. & Rossiter, S., 30 Nov 2020, In: International Journal of Molecular Sciences (IJMS). 21, 23, p. 1-19 19 p., 9134.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)51 Downloads (Pure) -
Discovery of novel small molecule inhibitors of S100P, with in vitro anti-metastatic effects on pancreatic cancer cells
Camara, R., Ogbeni, D., Gerstmann, L., Ostovar, M., Hurer, E., Scott, M., Mahmoud, N., Radon, T., Crnogorac-Jurcevic, T., Patel, P., Mackenzie, L. S., Chau, D., Kirton, S. & Rossiter, S., 1 Oct 2020, In: European Journal of Medicinal Chemistry. 203, 112621.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)108 Downloads (Pure) -
In silico structural evaluation of short cationic antimicrobial peptides
Passarini, I., Rossiter, S., Malkinson, J. & Zloh, M., 21 Jun 2018, In: Pharmaceutics. 10, 3, 72.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)142 Downloads (Pure)