Projects per year
Stewart Kirton joined the academic team at the School of Pharmacy in November 2008. Prior to this he spent seven years working as a research scientist for a number of pharmaceutical companies, specialising in computer-aided drug design and development. He is interested in exposing students to the computational methods and techniques which help underpin modern drug discovery projects, and hopes it will give them an understanding of how the medicines they deal with on a day-to-day basis originate. He holds a PhD in Chemistry.
- Computational Chemistry and its role in Drug Discovery and Development
- Drug Discovery and Design
- Drug-Receptor interactions at the molecular level.
- In Silico Prediction of metabolism via the Cytochromes P450 – particularly prediction of human only metabolites.
- In Silico design of natural product analogues.
- Comparative modelling of proteins.
- Design and development of databases for virtual screening.
- Computer modelling of aqueous solubility.
- Application of artificial neural networks to physicochemical property prediction.
- Computational design of potent, novel and selective molecules with potential as therapies for pancreatic cancer.
- Computational modelling of percutaneous absorption using QSAR/QSPR techniques
- The role of competency-based assessments in undergraduate degrees.
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Development of forensic methodologies for the in-field identification of opioids (prescription & designer) using Raman spectroscopic and chemometric approaches
Guirguis, A., Stair, J. & Kirton, S.
17/09/18 → 16/09/22
Ligand-protein studies for development of inhibitors of S100P, as a potential novel therapy for pancreatic cancer
Rossiter, S., Kirton, S. & Hyvönen, M.
1/04/18 → 31/12/19
KTP - Valve design optimisation
1/03/18 → 28/02/21
Assessing Knowledge and Enhancing Detection of Seized Psychoactive Substances in Prisons
Guirguis, A., Stair, J. & Kirton, S.
1/02/18 → 31/01/21
In Silico Investigations into the Selectivity of Psychoactive and New Psychoactive Substances in Monoamine TransportersKirton, S. & Botha, M., 1 Nov 2022, In: ACS Omega. 7, 43, p. 38311-38321 11 p.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile2 Downloads (Pure)
NPS detection in Prison: a Systematic Literature Review of Use, Drug Form, and Analytical ApproachesStair, J., Vaccaro, G., Guirguis, A., Kirton, S. & Massariol, A., 30 Mar 2022, (E-pub ahead of print) In: Drug Testing and Analysis. 31 p.
Research output: Contribution to journal › Review article › peer-reviewOpen AccessFile
Polymer Architecture Effects on Poly(N,N‐Diethyl Acrylamide)‐b‐Poly(Ethylene Glycol)‐b‐Poly(N,N‐Diethyl Acrylamide) Thermoreversible Gels and Their Evaluation as a Healthcare MaterialHaddow, P. J., da Silva, M. A., Kaldybekov, D. B., Dreiss, C. A., Hoffman, E., Hutter, V., Khutoryanskiy, V. V., Kirton, S. B., Mahmoudi, N., McAuley, W. J. & Cook, M. T., 11 Dec 2021, (E-pub ahead of print) In: Macromolecular Bioscience. 13 p., 2100432.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile12 Downloads (Pure)
Thermoresponsive Triblock‐Copolymers of Polyethylene Oxide and Polymethacrylates: Linking Chemistry, Nanoscale Morphology, and Rheological Propertiesda Silva, M. A., Haddow, P., Kirton, S. B., McAuley, W. J., Porcar, L., Dreiss, C. A. & Cook, M. T., 23 Nov 2021, (E-pub ahead of print) In: Advanced Functional Materials. 10 p., 2109010.
Research output: Contribution to journal › Article › peer-reviewOpen AccessFile17 Downloads (Pure)
Thermoresponsive triblock-copolymers of polyethylene oxide and polymethacrylates: linking chemistry, nanoscale morphology and rheological propertiesCook, M. T., McAuley, W., Kirton, S., Haddow, P., Alves da Silva, M. & Dreiss, C. A., 3 Nov 2021, In: Advanced Functional Materials.
Research output: Contribution to journal › Article › peer-reviewFile5 Downloads (Pure)