Personal profile
Overview
I am a lecturer in Neuropharmacology at the School of Health, Medicine and Life Sciences. My research interests are focused on behvioural and cognitive changes in neurodegenerative disease. I obtained my PhD in Neuroscience in 2017 from the University of Dundee School of Medicine where I investigated the neuroprotective effects of leptin mimetic agents in cellular models of Alzheimer's Disease in the research group of Professor Jenni Harvey. After completion of my PhD, I moved to the University of Exeter College of Medicine and Health to assess the effects of an orally active brain permeable AMPK activator on counterregulation following acute and recurrent hypoglycaemia in-vivo as a postdoctoral researcher within the research group of Dr Craig Beall and Professor Kate Ellacott. I started my second postdoctoral role with Drs Byron Creese and Aaron Jeffries at the same university to generate gene expression profiles for compounds with antipsychotic actions which are in various stages of clinical development and are relevant to the treatment of neuropsychiatric symptoms in AD. This work was in collaboration with the Complex Disease Epigenetics Group of Professor Jonathan Mill at Exeter and Eli lilly, UK. I started a new postdoctoral fellow position within the Neurodegenerative Disease Group of Professor Mahmoud Iravani at the University of Hertfordshire in 2019 where I examined the neuroprotective effects of nicotinic agents for treatment of LDOPA-induced dyskinesia in Parkinson's Disease in-vivo. This project was in collaboration with University of Newcastle.
I will continue my research in discovering therapeutic compounds for the treatment of LDOPA-induced dyskinesia and cognitive enhancing effects of nicotinic agents in Parkinson's Disease models. In the first instance, I will continue my collaboration with Professor Iravani's group at the University of Hertfordshire and expand our research with external collaborators, while submitting grant applications in the field of Alzheimer's disease.
I am also the Undergraduate admissions lead at the Biosciences group where I review application forms from home and international students and make a decision about the outcome of their application for enrolling into one of our BSc Bioscience courses within the School of Health, Medicine and Life Sciences.
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Collaborations and top research areas from the last five years
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Inhibition of levodopa-induced abnormal involuntary movements (AIMs) using a selective α7 nicotinic positive allosteric modulator
Malekizadeh, Y., Hassankhani, K., Kingslake, A. E., Annett, L. E., Shoaib, M. & Iravani, M. M., 15 Feb 2026, In: Neuropharmacology. 284, 12 p., 110786.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Leptin-based hexamers facilitate memory and prevent amyloid-driven AMPA receptor internalisation and neuronal degeneration
Doherty, G., Holiday, A., Malekizadeh, Y., Manolescu, C., Duncan, S., Flewitt, I., Hamilton, K., MacLeod, B., Ainge, J. A. & Harvey, J., 29 Nov 2022, (E-pub ahead of print) Journal of Neurochemistry (JNC), p. 18.Research output: Contribution to specialist publication › Article
Open AccessFile9 Citations (Scopus)22 Downloads (Pure) -
Brain Permeable AMP-Activated Protein Kinase Activator R481 Raises Glycaemia by Autonomic Nervous System Activation and Amplifies the Counterregulatory Response to Hypoglycaemia in Rats
Cruz, A. M., Partridge, K. M., Malekizadeh, Y., Vlachaki Walker, J. M., Weightman Potter, P. G., Pye, K. R., Shaw, S. J., Ellacott, K. L. J. & Beall, C., 17 Dec 2021, In: Frontiers in Endocrinology. 12, p. 697445Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects
Malekizadeh, Y., Williams, G., Kelson, M., Whitfield, D., Mill, J., Collier, D. A., Ballard, C., Jeffries, A. R. & Creese, B., 24 Aug 2020, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 6, 1, e12078.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus) -
A Leptin Fragment Mirrors the Cognitive Enhancing and Neuroprotective Actions of Leptin
Malekizadeh, Y., Holiday, A., Redfearn, D., Ainge, J. A., Doherty, G. & Harvey, J., 1 Oct 2016, In: Cerebral cortex (New York, N.Y. : 1991). 27, 10, p. 4769-4782 14 p.Research output: Contribution to journal › Article › peer-review
38 Citations (Scopus)