Does Incremental Initiation of Haemodialysis Preserve Native Kidney Function? A Multicentre Feasibility Randomised Control Trial.

Project: Other

Project Details


There is increasing evidence that Residual Kidney Function (RKF) is a major contributor to long-term survival in both the Haemodialysis (HD) and Peritoneal Dialysis (PD) population. Dialysis strategies that protect RKF may therefore be beneficial. Both prospective and retrospective non-randomised studies have demonstrated that patients commencing twice-weekly haemodialysis have a slower rate of decline of RKF. Incremental dialysis uses the concept of individualising dialysis dose according to RKF. To determine whether in-centre incremental dialysis compared to standard 3 times weekly haemodialysis preserves RKF would require a major randomised controlled trial. A pilot feasibility study needs to be conducted to answer some key questions to inform the design of the definitive RCT. This pilot feasibility study will be conducted in 4 centres. Fifty patients will be randomised (1:1) to either conventional 3 times weekly HD or an incremental HD protocol and will be followed up for 12 months after randomisation.
Short titleIncremental Dialysis Study
Effective start/end date6/03/1831/08/20


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