Exploring the therapeutic potential of TRPV1 antagonism in diabetes without hyperthermia

Project: Research

Project Details

Key findings

Daily administration of the TRPV1 antagonist ABT-102 over 9 days did not cause significant hyperthemia in STZ-diabetic rats from days 2-9, but did significantly reverse the static allodynia associated with diabetic neuropathy (in line with pregabalin efficacy), confirming the hypothesis that TRPV1 function is altered peripherally in diabetes. These data demonstrate that there is a potential for treatment of diabetic neuropathy by TRPV1 antagonists.

Key data will be presented at the BPS Pharmacology conference (London, 2017) and is to be submitted to a peer reviewed pain journal.

Effective start/end date7/06/1725/07/17


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