Immunohistochemical localisation of dopaminergic, noradrenergic, serotoninergic and cholinergic neurones in the prefrontal cortex and the hippocampus in a primate model of Parkinson’s disease

Project: Other

Project Details


It has been estimated that approximately half of the Parkinson’s disease sufferers will develop cognitive deficits such as forgetfulness, difficulty doing simple mathematical tasks, difficulty in understanding subtleties of language and inability to interpret sensations during the early stages of the disease. These difficulties arise from the prefrontal cortex and hippocampus. Evidence in man
suggests that both the higher executive centres and the lower memory retrieval centre seem to be adversely affected in PD patients with cognitive decline. Currently, there is no way of treating cognitive decline and drugs that PD sufferer take to alleviate their movement problems may in fact worsen cognition. The aim of this experiment is to look for three main nerve types that are known
to be involved in the process of cognition. For this reason, we want to study the brains of monkeys that are no longer alive but were used in PD research previously.
Effective start/end date1/06/1726/07/17


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