Investigating the patient-inhaler interface to improve and personalise drug delivery to the lungs of asthmatic patients

Project: Research

Project Details


5.2 million people live with asthma in the UK. Despite the availability of effective therapies, mortality rates have shown little improvement in the last 20 years. One explanation for the poor impact of therapies on mortality relates to patients’ inability to use their inhaler device correctly – as many as 94 % of patients. Many suffering from asthma and obstructive lung diseases are unable to effectively generate an aerosol cloud from dry powder inhalers (DPI) leading to high variability and low fractions of a dose depositing in the lung (5.5-28 %), There is scant information on the optimum DPI formulation/device combination to match a patient's inhalation profile. This project aims to investigate the link between how patients inhale through their devices, and whether it is possible to choose the optimum formulation and DPI device for that patient based on a simple spirometric measurement.

Key findings

The project is ongoing, however, we have successfully developed a spirometric tool for rapid inhalation profile screening in clinics. We are now seeking ethical approval to work with our clinical partners in an asthma clinic.
Effective start/end date1/06/121/07/15


  • The Aerosol Society: £7,500.00


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