Tracking the metabolic signatures associated with the fatal childhood motor neuron disorder Spinal Muscular Atrophy (SMA)

Royal Society Research Grant Award

Spinal muscular atrophy (SMA) is the most common motor neuron disease ofinfancy. The study proposed herein draws on the strengths of invertebrate andvertebrate models in order to track the metabolic changes associated with SMApathogenesis, thus providing an alternative area for biomarker identification anddrug target development for SMA-affected infants.