240 Influence of smoking status on cancer recurrence following curative intent surgery in lung cancer

Introduction
Cigarette smoking continues to pose a substantial risk for the development of lung cancer (1). Lung cancer in never smokers (LCINS) exhibits distinct epidemiological, clinicopathological, and molecular features when compared to lung cancer in individuals with a history of smoking (2,3).
Method
Patients diagnosed with non-small cell lung carcinoma at the ENH NHS Trust who underwent curative intent surgery between 2010 to 2019, were systematically reviewed for demographic influence, including smoking status, on post surgical recurrence...
Results
Of 252 patients reviewed, 203 patients had smoking status recorded. 189 (93.1%) were ever smokers, including current smokers and former smokers who had discontinued smoking either prior to or after the diagnosis of NSCLC, while 14 cases (6.90%) were never smokers. 28.57% of never-smokers experienced cancer recurrence, while 21.69% of ever smokers experienced cancer recurrence. The prevalence of cancer recurrence in individuals who had never smoked was higher than ever smokers by 8%. This could...