3D printing of drug-loaded gyroid lattices using selective laser sintering

Fabrizio Fina, Alvaro Goyanes, Christine M. Madla, Atheer Awad, Sarah J. Trenfield, Jia Min Kuek, Pavanesh Patel, Simon Gaisford, Abdul W. Basit

Research output: Contribution to journalArticlepeer-review

156 Citations (Scopus)


Three-dimensional printing (3DP) is gaining momentum in the field of pharmaceuticals, offering innovative opportunities for medicine manufacture. Selective laser sintering (SLS) is a novel, high resolution and single-step printing technology that we have recently introduced to the pharmaceutical sciences. The aim of this work was to use SLS 3DP to fabricate printlets (3D printed tablets) with cylindrical, gyroid lattice and bi-layer structures having customisable release characteristics. Paracetamol-loaded constructs from four different pharmaceutical grade polymers including polyethylene oxide, Eudragit (L100-55 and RL) and ethyl cellulose, were created using SLS 3DP. The novel gyroid lattice structure was able to modulate the drug release from all four polymers. This work is the first to demonstrate the feasibility of using SLS to achieve customised drug release properties of several polymers, in a swift, cost-effective manner, avoiding the need to alter the formulation composition. By creating these constructs, it is therefore possible to modify drug release, which in practice, could enable the tailoring of drug performance to the patient simply by changing the 3D design.

Original languageEnglish
Pages (from-to)44-52
Number of pages9
JournalInternational Journal of Pharmaceutics
Issue number1-2
Publication statusPublished - 25 Aug 2018


  • Acrylic polymers
  • Additive manufacturing
  • Fused deposition modeling (FDM)
  • Personalized medicines
  • Rapid prototyping
  • Stereolithography (SLA)


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