3D‑printed biomimetic bone implant polymeric composite scaffolds

O.  Bankole; Abolfazl Zahedi; S. Ismail; W.  Fernando; O. Ikumapayi

doi:10.1007/s00170-023-11344-x

3D‑printed biomimetic bone implant polymeric composite scaffolds

O. Bankole, Abolfazl Zahedi, S. Ismail, W. Fernando, O. Ikumapayi

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Abstract

This research introduced a new poly-ether-ether-ketone calcium hydroxyapatite (PEEK-cHAp) composite for a convenient,
fast, and inexpensive femur bone-implant scaffold with different lattice structures to mimic natural bone structure. Fused
deposition modelling (FDM) was used to print a hybrid PEEK-based filament-bearing bioactive material suited for developing cHAp. Using FDM, the same bone scaffold PEEK will be fabricated, depending on the shape of the bone fracture. The scaffolds were examined for in vitro bioactivity by immersing them in a simulated bodily fluid (SBF) solution. Furthermore, in vitro cytotoxicity tests validated the suitability of the composite materials employed to create minimal toxicity of the scaffolds. After spreading PEEK nanoparticles in the grains, the suggested spherical nanoparticle cell expanded over time. The motif affected the microstructure of PEEK-cHAp in terms of grain size and 3D shape. The results established the proposed optimum design and suitable material for prospective bone implants, as required for biomimetic artificial bone regeneration and healing.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	International Journal of Advanced Manufacturing Technology
DOIs	https://doi.org/10.1007/s00170-023-11344-x
Publication status	Published - 14 Apr 2023

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© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Final published version, 1.15 MBLicence: CC BY

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title = "3D‑printed biomimetic bone implant polymeric composite scaffolds",

abstract = "This research introduced a new poly-ether-ether-ketone calcium hydroxyapatite (PEEK-cHAp) composite for a convenient,fast, and inexpensive femur bone-implant scaffold with different lattice structures to mimic natural bone structure. Fuseddeposition modelling (FDM) was used to print a hybrid PEEK-based filament-bearing bioactive material suited for developing cHAp. Using FDM, the same bone scaffold PEEK will be fabricated, depending on the shape of the bone fracture. The scaffolds were examined for in vitro bioactivity by immersing them in a simulated bodily fluid (SBF) solution. Furthermore, in vitro cytotoxicity tests validated the suitability of the composite materials employed to create minimal toxicity of the scaffolds. After spreading PEEK nanoparticles in the grains, the suggested spherical nanoparticle cell expanded over time. The motif affected the microstructure of PEEK-cHAp in terms of grain size and 3D shape. The results established the proposed optimum design and suitable material for prospective bone implants, as required for biomimetic artificial bone regeneration and healing.",

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AU - Zahedi, Abolfazl

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AU - Fernando, W.

AU - Ikumapayi, O.

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N2 - This research introduced a new poly-ether-ether-ketone calcium hydroxyapatite (PEEK-cHAp) composite for a convenient,fast, and inexpensive femur bone-implant scaffold with different lattice structures to mimic natural bone structure. Fuseddeposition modelling (FDM) was used to print a hybrid PEEK-based filament-bearing bioactive material suited for developing cHAp. Using FDM, the same bone scaffold PEEK will be fabricated, depending on the shape of the bone fracture. The scaffolds were examined for in vitro bioactivity by immersing them in a simulated bodily fluid (SBF) solution. Furthermore, in vitro cytotoxicity tests validated the suitability of the composite materials employed to create minimal toxicity of the scaffolds. After spreading PEEK nanoparticles in the grains, the suggested spherical nanoparticle cell expanded over time. The motif affected the microstructure of PEEK-cHAp in terms of grain size and 3D shape. The results established the proposed optimum design and suitable material for prospective bone implants, as required for biomimetic artificial bone regeneration and healing.

AB - This research introduced a new poly-ether-ether-ketone calcium hydroxyapatite (PEEK-cHAp) composite for a convenient,fast, and inexpensive femur bone-implant scaffold with different lattice structures to mimic natural bone structure. Fuseddeposition modelling (FDM) was used to print a hybrid PEEK-based filament-bearing bioactive material suited for developing cHAp. Using FDM, the same bone scaffold PEEK will be fabricated, depending on the shape of the bone fracture. The scaffolds were examined for in vitro bioactivity by immersing them in a simulated bodily fluid (SBF) solution. Furthermore, in vitro cytotoxicity tests validated the suitability of the composite materials employed to create minimal toxicity of the scaffolds. After spreading PEEK nanoparticles in the grains, the suggested spherical nanoparticle cell expanded over time. The motif affected the microstructure of PEEK-cHAp in terms of grain size and 3D shape. The results established the proposed optimum design and suitable material for prospective bone implants, as required for biomimetic artificial bone regeneration and healing.

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3D‑printed biomimetic bone implant polymeric composite scaffolds

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