A cross‐sectional study of the prevalence and clinical management of atherosclerotic cardiovascular diseases in patients with type 2 diabetes across the Middle East and Africa ( PACT‐MEA ): Study design and rationale

Subodh Verma, Hani Sabbour, Naji Alamuddin, Fatheya Alawadi, Hessa Alkandari, Wael Almahmeed, Samir H. Assaad‐Khalil, Jihad Haddad, Landman Lombard, Rayaz A. Malik, Emel Mashaki Ceyhan, Preethy Prasad, Gamze Tombak, Sam Salek

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Abstract

Aim: To investigate the epidemiology and clinical management of patients with type 2 diabetes (T2D) and established atherosclerotic cardiovascular disease (eASCVD) or high/very high ASCVD risk, defined by the 2021 European Society of Cardiology Guidelines, in seven countries in the Middle East and Africa (PACT‐MEA; NCT05317845), and to assess physicians' attitudes and the basis for their decision‐making in the management of these patients. Materials and Methods: PACT‐MEA is a cross‐sectional, observational study undertaken in Bahrain, Egypt, Jordan, Kuwait, Qatar, South Africa and the United Arab Emirates based on a medical chart review of approximately 3700 patients with T2D in primary and secondary care settings, and a survey of approximately 400 physicians treating patients with T2D. Results: The primary and secondary objectives are to determine the prevalence of eASCVD and high/very high ASCVD risk in patients with T2D. Current treatment with cardioprotective antidiabetic medication, the proportion of patients meeting the treatment criteria for reimbursement in the study countries where there is an applicable reimbursement guideline, and physician‐reported factors in clinical decision‐making in T2D management, will also be assessed. Conclusions: This large cross‐sectional study will establish the estimated prevalence and management of eASCVD and high/very high ASCVD risk in patients with type 2 diabetes across the Middle East and Africa.
Original languageEnglish
Pages (from-to)1444-1452
Number of pages9
JournalDiabetes, Obesity and Metabolism (DOM)
Volume25
Issue number6
Early online date3 Mar 2023
DOIs
Publication statusE-pub ahead of print - 3 Mar 2023

Keywords

  • CLINICAL STUDY DESIGN
  • Africa
  • atherosclerosis
  • cardiovascular diseases
  • diabetes complications
  • epidemiology
  • Middle East
  • prevalence
  • type 2 diabetes

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