A Genomic Regulatory Network for Development

E.H. Davidson; J.P. Rast; P. Oliveri; A. Ransick; C. Calestani; C.H. Yuh; T. Minokawa; G. Amore; V. Hinman; C. Arenas-Mena; A. Otim; C.T. Brown; C.B. Livi; P.Y. Lee; R. Revilla; A.G. Rust; Z. Pan; M. Schilstra; P.J.C. Clarke; M.I. Arnone; L. Rowen; R.A. Cameron; D.R. McClay; L. Hood; H. Bolouri

doi:10.1126/science.1069883

A Genomic Regulatory Network for Development

E.H. Davidson, J.P. Rast, P. Oliveri, A. Ransick, C. Calestani, C.H. Yuh, T. Minokawa, G. Amore, V. Hinman, C. Arenas-Mena, A. Otim, C.T. Brown, C.B. Livi, P.Y. Lee, R. Revilla, A.G. Rust, Z. Pan, M. Schilstra, P.J.C. Clarke, M.I. ArnoneL. Rowen, R.A. Cameron, D.R. McClay, L. Hood, H. Bolouri

Research output: Contribution to journal › Article › peer-review

1134 Citations (Scopus)

Abstract

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

Original language	English
Pages (from-to)	1669-1678
Journal	Science
Volume	295
Issue number	5560
DOIs	https://doi.org/10.1126/science.1069883
Publication status	Published - 2002

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Davidson, E. H., Rast, J. P., Oliveri, P., Ransick, A., Calestani, C., Yuh, C. H., Minokawa, T., Amore, G., Hinman, V., Arenas-Mena, C., Otim, A., Brown, C. T., Livi, C. B., Lee, P. Y., Revilla, R., Rust, A. G., Pan, Z., Schilstra, M., Clarke, P. J. C., ... Bolouri, H. (2002). A Genomic Regulatory Network for Development. Science, 295(5560), 1669-1678. https://doi.org/10.1126/science.1069883

@article{ce511dc94d684a529f5a41548df04598,

title = "A Genomic Regulatory Network for Development",

abstract = "Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time. ",

author = "E.H. Davidson and J.P. Rast and P. Oliveri and A. Ransick and C. Calestani and C.H. Yuh and T. Minokawa and G. Amore and V. Hinman and C. Arenas-Mena and A. Otim and C.T. Brown and C.B. Livi and P.Y. Lee and R. Revilla and A.G. Rust and Z. Pan and M. Schilstra and P.J.C. Clarke and M.I. Arnone and L. Rowen and R.A. Cameron and D.R. McClay and L. Hood and H. Bolouri",

note = "Original article can be found at: http://www.sciencemag.org/ Copyright American Association for the Advancement of Science. [Full text of this article is not available in the UHRA]",

year = "2002",

doi = "10.1126/science.1069883",

language = "English",

volume = "295",

pages = "1669--1678",

journal = "Science",

issn = "0036-8075",

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Davidson, EH, Rast, JP, Oliveri, P, Ransick, A, Calestani, C, Yuh, CH, Minokawa, T, Amore, G, Hinman, V, Arenas-Mena, C, Otim, A, Brown, CT, Livi, CB, Lee, PY, Revilla, R, Rust, AG, Pan, Z, Schilstra, M, Clarke, PJC, Arnone, MI, Rowen, L, Cameron, RA, McClay, DR, Hood, L & Bolouri, H 2002, 'A Genomic Regulatory Network for Development', Science, vol. 295, no. 5560, pp. 1669-1678. https://doi.org/10.1126/science.1069883

TY - JOUR

T1 - A Genomic Regulatory Network for Development

AU - Davidson, E.H.

AU - Rast, J.P.

AU - Oliveri, P.

AU - Ransick, A.

AU - Calestani, C.

AU - Yuh, C.H.

AU - Minokawa, T.

AU - Amore, G.

AU - Hinman, V.

AU - Arenas-Mena, C.

AU - Otim, A.

AU - Brown, C.T.

AU - Livi, C.B.

AU - Lee, P.Y.

AU - Revilla, R.

AU - Rust, A.G.

AU - Pan, Z.

AU - Schilstra, M.

AU - Clarke, P.J.C.

AU - Arnone, M.I.

AU - Rowen, L.

AU - Cameron, R.A.

AU - McClay, D.R.

AU - Hood, L.

AU - Bolouri, H.

N1 - Original article can be found at: http://www.sciencemag.org/ Copyright American Association for the Advancement of Science. [Full text of this article is not available in the UHRA]

PY - 2002

Y1 - 2002

N2 - Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

AB - Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

U2 - 10.1126/science.1069883

DO - 10.1126/science.1069883

M3 - Article

SN - 0036-8075

VL - 295

SP - 1669

EP - 1678

JO - Science

JF - Science

IS - 5560

ER -

A Genomic Regulatory Network for Development

Abstract

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