A hydrogen generator composed of poly (lactic-co-glycolic acid) nanofiber membrane loaded iron nanoparticles for infectious diabetic

Diabetic wounds, a chronic skin disease, pose a significant challenge in clinical practice due to their persistent inflammation and impaired angiogenesis. Recently, hydrogen has emerged as a novel therapeutic approach, owing to its superior antioxidant and anti-inflammatory properties. Therefore, in this study, we have engineered a poly (lactic-co-glycolic acid) (PLGA) electrospinning nanofiber membrane, loaded with citric acid (CA) and iron (Fe) nanoparticles, referred to as Fe@PLGA+CA. Our in vitro assays demonstrate that the Fe@PLGA+CA membrane could continuously generate and release hydrogen molecules caused by a chemical reaction between Fe and CA in the acidic microenvironment created by CA. We also discovered that hydrogen has the potential to ameliorate fibroblast migration disorders inflammatory reactions. This, in turn, promotes vessel formation, following by promoting wound healing and accelerated skin regeneration processes. These findings opened up new possibilities for using elemental Fe in skin dressings and bring us one step closer to implementing hydrogen-releasing biomedical materials in clinical practice.