TY - JOUR
T1 - A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids
AU - Cook, Michael
N1 - This document is the Accepted Manuscript version of the following article: Jessica Bassi da Silva, Vitaliy V. Khutoryanskiy, Marcos L. Bruschi, and Michael T. Cook, ‘A mucosa-mimetic material for the mucoadhesion testing of thermogelling semi-solids’, International Journal of Pharmaceutics, vol. 528 (1-2): 586-594, August 2017. Under embargo. Embargo end date: 15 June 2018.
© 2017 Elsevier B.V. All rights reserved.
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.
PY - 2017/8/7
Y1 - 2017/8/7
N2 - Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for animal mucosae in the mucoadhesion testing of tablets and solution formulations. This study aims to investigate the efficacy of this mucosa-mimetic material in the testing of thermogelling semi-solid formulations, which transition from solution to gel upon warming. Two methods for assessing mucoadhesion have been used; tensile testing and a flow-through system, which allow for investigation under dramatically different conditions. It was found that the mucosa-mimetic material was a good surrogate for buccal mucosa using both testing methods. This material may be used to replace animal tissue in these experiments, potentially reducing the number of laboratory animals used in studies of this type.
AB - Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-d-glucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for animal mucosae in the mucoadhesion testing of tablets and solution formulations. This study aims to investigate the efficacy of this mucosa-mimetic material in the testing of thermogelling semi-solid formulations, which transition from solution to gel upon warming. Two methods for assessing mucoadhesion have been used; tensile testing and a flow-through system, which allow for investigation under dramatically different conditions. It was found that the mucosa-mimetic material was a good surrogate for buccal mucosa using both testing methods. This material may be used to replace animal tissue in these experiments, potentially reducing the number of laboratory animals used in studies of this type.
U2 - 10.1016/j.ijpharm.2017.06.025
DO - 10.1016/j.ijpharm.2017.06.025
M3 - Article
SN - 0378-5173
VL - 528
SP - 586
EP - 594
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -