A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches

Muhammet Emin Cam, Ayse Nur Hazar-Yavuz, Sumeyye Cesur, Ozan Ozkan, Hussain Alenezi, Hilal Turkoglu Sasmazel, Mehmet Sayip Eroglu, Francis Brako, Jubair Ahmed, Levent Kabasakal, Guogang Ren, Oguzhan Gunduz, Mohan Edirisinghe

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
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Abstract

Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for intra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.
Original languageEnglish
Article number119782
Number of pages15
JournalInternational Journal of Pharmaceutics
Volume588
Early online date19 Aug 2020
DOIs
Publication statusPublished - 15 Oct 2020

Keywords

  • Electrospinning
  • Fibers
  • Polymeric patch
  • Pressurized gyration
  • Preterm birth
  • Progesterone

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