A paradigm shift in enteric coating: achieving rapid release in the proximal small intestine of man

Fang Liu, A.W. Basit

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)


The in vivo performance of a novel enteric double-coating technology designed to accelerate release in the proximal small intestine of humans was investigated. Tablet cores were coated with a double layer formulation consisting of an inner layer of EUDRAGIT® L 30 D-55 neutralised to pH 6.0 in the presence of 10% citric acid, and an outer layer of standard EUDRAGIT® L 30 D-55. A conventional single coating of EUDRAGIT® L 30 D-55 was also applied to tablets for comparison purposes, with the identical coating formulation and thickness (5 mg/cm2) as the outer layer of the double coating. Eight fasted volunteers received the double-coated and single-coated tablets in a two-way crossover study. The formulations were radiolabelled and followed by gamma scintigraphy; the disintegration times and positions were recorded. After leaving the stomach, tablets coated with the single-coating formulation showed a significant time delay before disintegration occurred in the mid to distal small intestine, with a mean disintegration time of 66 ± 22 min post gastric emptying. The double-coated tablets disintegrated earlier at 28 ± 6 min post gastric emptying with consistent disintegration in the proximal small intestine. The accelerated in vivo disintegration of the double-coating system can overcome the limitations of conventional enteric coating.
Original languageEnglish
Pages (from-to)242-245
JournalJournal of Controlled Release
Issue number2
Publication statusPublished - 2010


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