A potential anti-implantation and spermicidal strategy: Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity

M.J. Ingram; E. Zeller; G.P. Moss; C.E. Hall

doi:10.1080/13625180600907487

A potential anti-implantation and spermicidal strategy: Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity

M.J. Ingram, E. Zeller, G.P. Moss, C.E. Hall

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We report the synthesis of novel ester derivatives of nonoxynol-9, an approved spermicidal agent, using the non-steroidal inflammatory drugs (NSAIDs) ibuprofen and indomethacin. Indomethacin has previously been shown to inhibit the implantation of the fertilised ovum into the uterus wall of pregnant rats. It is proposed that nonoxynol-9, in combination with a non-selective NSAID may exhibit both anti-implantation and spermicidal properties.

Read More: http://informahealthcare.com/doi/abs/10.1080/13625180600907487

Original language	English
Pages (from-to)	258-261
Journal	European Journal of Contraception and Reproductive Healthcare
Volume	11
Issue number	4
DOIs	https://doi.org/10.1080/13625180600907487
Publication status	Published - 2006

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10.1080/13625180600907487

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title = "A potential anti-implantation and spermicidal strategy: Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity",

abstract = "We report the synthesis of novel ester derivatives of nonoxynol-9, an approved spermicidal agent, using the non-steroidal inflammatory drugs (NSAIDs) ibuprofen and indomethacin. Indomethacin has previously been shown to inhibit the implantation of the fertilised ovum into the uterus wall of pregnant rats. It is proposed that nonoxynol-9, in combination with a non-selective NSAID may exhibit both anti-implantation and spermicidal properties. Read More: http://informahealthcare.com/doi/abs/10.1080/13625180600907487",

author = "M.J. Ingram and E. Zeller and G.P. Moss and C.E. Hall",

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T2 - Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity

AU - Ingram, M.J.

AU - Zeller, E.

AU - Moss, G.P.

AU - Hall, C.E.

N1 - Original article can be found at: http://www.informaworld.com/smpp/title~content=t713604167 Copyright Informa. [Full text of this article is not available in the UHRA]

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N2 - We report the synthesis of novel ester derivatives of nonoxynol-9, an approved spermicidal agent, using the non-steroidal inflammatory drugs (NSAIDs) ibuprofen and indomethacin. Indomethacin has previously been shown to inhibit the implantation of the fertilised ovum into the uterus wall of pregnant rats. It is proposed that nonoxynol-9, in combination with a non-selective NSAID may exhibit both anti-implantation and spermicidal properties. Read More: http://informahealthcare.com/doi/abs/10.1080/13625180600907487

AB - We report the synthesis of novel ester derivatives of nonoxynol-9, an approved spermicidal agent, using the non-steroidal inflammatory drugs (NSAIDs) ibuprofen and indomethacin. Indomethacin has previously been shown to inhibit the implantation of the fertilised ovum into the uterus wall of pregnant rats. It is proposed that nonoxynol-9, in combination with a non-selective NSAID may exhibit both anti-implantation and spermicidal properties. Read More: http://informahealthcare.com/doi/abs/10.1080/13625180600907487

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DO - 10.1080/13625180600907487

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SP - 258

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JO - European Journal of Contraception and Reproductive Healthcare

JF - European Journal of Contraception and Reproductive Healthcare

IS - 4

ER -

A potential anti-implantation and spermicidal strategy: Putative derivatives of nonoxynol-9 and anti-inflammatory agents and their spermicidal activity

Abstract

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