A silicon micromachined device for use in blood cell deformability studies

M.C. Tracey, R. S. Greenaway, A. Das, Paul H. Kaye, A. J. Barnes

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


An application of silicon micromachining to the analysis of blood cell theology is described. The system, based upon a micromachined flow cell, provides a specific measurement of each cell in a statistically significant population in terms of both flow velocity profile and an index of cell volume while the cells flow through an array of microchannels. The-rationale, design, and fabrication of the silicon micromachined flow cell is discussed. Interrelated considerations determining the design of the associated fluidic, mechanical, imaging, and real-time image analysis subsystems are examined. Sample data comparing normal and iron deficiency anaemic blood are presented to illustrate the potential of this technique.

Original languageEnglish
Pages (from-to)751-761
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Issue number8
Publication statusPublished - Aug 1995


  • erythrocyte deformability
  • filterability
  • rheology
  • micropore
  • flow


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