Action potential backpropagation in a model thalamocortical relay cell

Nada A.B. Yousif, Mike Denham

Research output: Contribution to journalArticlepeer-review


Thalamocortical (TC) cells relay most sensory information to the neocortex. Sensory and cortical afferents are segregated in TC cells, and the way these inputs are integrated is important to understanding the role of TC cells in sensory processing. Experimental results indicate that backpropagating action potentials effect synaptic integration. We investigate backpropagation in a previously described multi-compartment model of a TC cell, and compare simulation results with experimental results. The model does not replicate the results well, and we suggest changes that improve these results but affect the firing modes of the model. This has repercussions for models of thalamocortical signalling.

Original languageEnglish
Pages (from-to)393-400
Number of pages8
Publication statusPublished - Jun 2004
Externally publishedYes


  • Backpropagation
  • Multi-compartment model
  • Thalamocortical


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